4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide | 1446113-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
• 英文别名: 4-amino-N-[1-(3-chloro-4-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide
• CAS: 1446113-05-8
• 化学式: C₂₃H₁₆ClFN₆OS
• 分子量: 478.937
• InChiKey: GNDBDDNLWIOKDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [EN] THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES<br/>[FR] DÉRIVÉS THIÉNO[3,2-D]PYRIMIDINES AYANT UNE ACTIVITÉ INHIBITRICE POUR DES PROTÉINES KINASES
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2013100632A1

  公开（公告）日：2013-07-04

  Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

  提供一种具有蛋白激酶抑制活性的噻吩[3,2-d]嘧啶衍生物（化学式（I））或其药用可接受的盐，以及包含该衍生物的药物组合物，用于预防和治疗异常细胞生长疾病。
• THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES
  申请人：HANMI PHARM. CO., LTD

  公开号：US20140371219A1

  公开（公告）日：2014-12-18

  Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

  提供一种具有蛋白激酶抑制活性的噻吩[3,2-d]嘧啶衍生物的化学式(I)或其药用可接受盐，以及包含该化合物的药物组合物，用于预防和治疗异常细胞生长疾病。
• [EN] SALTS OF 4-AMINO-N-(1-((3-CHLORO-2-FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE, AND CRYSTALLINE FORMS THEREOF<br/>[FR] SELS DE 4-AMINO-N- (1-((3-CHLORO-2-FLUOROPHÉNYL) AMINO)-6-MÉTHYLISOQUINOLINE-5-YL) THIÉNO [3,2-D] PYRIMIDINE-7-CARBOXAMIDE ET LEURS FORMES CRISTALLINES
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2019107971A1

  公开（公告）日：2019-06-06

  The present invention relates to a crystalline form of a salt of 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide, and a pharmaceutical composition containing the same. The crystalline form of the salt of the compound can be easily used for preparing a pharmaceutical composition containing the same as an active ingredient.

  本发明涉及一种4-氨基-N-(1-((3-氯-2-氟苯基)氨基)-6-甲基异喹啉-5-基)噻吩[3,2-d]嘧啶-7-羧酰胺盐的晶体形式和含有该晶体形式的药物组合物。该化合物的盐的晶体形式可轻松用于制备含有该化合物作为活性成分的药物组合物。
• THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP2797927B1

  公开（公告）日：2019-09-25
• SALTS OF 4-AMINO-N-(1-((3-CHLORO-2-FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE, AND CRYSTALLINE FORMS THEREOF
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP3717489A1

  公开（公告）日：2020-10-07