4-bromo-1,8-bis(hydroxymethyl)naphthalene | 408333-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-bromo-1,8-bis(hydroxymethyl)naphthalene
• 英文别名: 1-bromo-4,5-bis-hydroxymethyl-naphthalene；1-Brom-4,5-bis-hydroxymethyl-naphthalin；[5-Bromo-8-(hydroxymethyl)naphthalen-1-yl]methanol
• CAS: 408333-05-1
• 化学式: C₁₂H₁₁BrO₂
• 分子量: 267.122
• InChiKey: IPLMQHYCGYNXEO-UHFFFAOYSA-N

物化性质

• 熔点：
  162-163.5 °C
• 沸点：
  466.4±35.0 °C(Predicted)
• 密度：
  1.596±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-bromo-1,8-bis(hydroxymethyl)naphthalene 在 三溴化磷 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 12.0h， 以70%的产率得到4-溴-1,8-二(溴甲基)萘
  参考文献：
  名称：

  Synthesis and Properties of Dicarboximide Derivatives of Perylene and Azaperylene

  摘要：

  The N-alkyl dicarboximide derivatives of naphthylisoquinoline and binaphthalene were prepared by the hetero coupling reaction of the corresponding N-alkyl dicarboximide derivatives of stannylnaphthalene with bromodimethyisoquinoline and bromodimethylnaphthalene, respectively. The ring closing of the N-hexyl derivatives of naphthylisoquinoline and binaphthalene produced the N-hexyldicarboximide derivatives of azaperylene and perylene having the same substituents, respectively. The absorption spectra and fluorescence spectra of the azaperylene and perylene derivatives were investigated.

  DOI：

  10.3987/com-09-s(s)104
• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 48.0h， 以64%的产率得到4-bromo-1,8-bis(hydroxymethyl)naphthalene
  参考文献：
  名称：

  Synthesis and Properties of Dicarboximide Derivatives of Perylene and Azaperylene

  摘要：

  The N-alkyl dicarboximide derivatives of naphthylisoquinoline and binaphthalene were prepared by the hetero coupling reaction of the corresponding N-alkyl dicarboximide derivatives of stannylnaphthalene with bromodimethyisoquinoline and bromodimethylnaphthalene, respectively. The ring closing of the N-hexyl derivatives of naphthylisoquinoline and binaphthalene produced the N-hexyldicarboximide derivatives of azaperylene and perylene having the same substituents, respectively. The absorption spectra and fluorescence spectra of the azaperylene and perylene derivatives were investigated.

  DOI：

  10.3987/com-09-s(s)104

文献信息

• A New Synthesis of Acenaphthene
  作者：Ernst D. Bergmann、Jacob Szmuszkovicz

  DOI：10.1021/ja01107a501

  日期：1953.6
• Ghilardi et al., Bulletin de la Societe Chimique de France, 1953, p. 407
  作者：Ghilardi et al.

  DOI：——

  日期：——