3-(6-Methoxynaphthalen-2-yl)-8a-methyl-2-(2-phenylethynyl)indolizin-1-one | 1221509-10-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(6-Methoxynaphthalen-2-yl)-8a-methyl-2-(2-phenylethynyl)indolizin-1-one
• CAS: 1221509-10-9
• 化学式: C₂₈H₂₁NO₂
• 分子量: 403.48
• InChiKey: QJWSCAJFKNKEPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-Iodo-3-(6-methoxynaphthalen-2-yl)-8a-methylindolizin-1-one 、 苯乙炔 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以70%的产率得到3-(6-Methoxynaphthalen-2-yl)-8a-methyl-2-(2-phenylethynyl)indolizin-1-one
  参考文献：
  名称：

  Diversity-Oriented Construction of Highly Substituted Indolizinones

  摘要：

  Rapid generation of small library of highly functionalized indolizonones was realized by exploiting three palladium-catalyzed cross-coupling reactions of 2-iodoindolizinones which in turn were readily accessed via sequential iodine-mediated cyclization/1,2-shift reactions of propargylic alcohols.

  DOI：

  10.1021/cc100015k

文献信息

• Diversity-Oriented Construction of Highly Substituted Indolizinones
  作者：Kyungsun Kim、Ikyon Kim

  DOI：10.1021/cc100015k

  日期：2010.5.10

  Rapid generation of small library of highly functionalized indolizonones was realized by exploiting three palladium-catalyzed cross-coupling reactions of 2-iodoindolizinones which in turn were readily accessed via sequential iodine-mediated cyclization/1,2-shift reactions of propargylic alcohols.