(1'R,4'aS,6'aS,10'aS,10'bR)-1'-(methoxymethoxy)-6'a,10'b-dimethylspiro[1,3-dioxolane-2,7'-2,4a,5,6,8,9,10,10a-octahydro-1H-benzo[f]chromene]-3'-one | 1225381-68-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: (1'R,4'aS,6'aS,10'aS,10'bR)-1'-(methoxymethoxy)-6'a,10'b-dimethylspiro[1,3-dioxolane-2,7'-2,4a,5,6,8,9,10,10a-octahydro-1H-benzo[f]chromene]-3'-one
• CAS: 1225381-68-9
• 化学式: C₁₉H₃₀O₆
• 分子量: 354.444
• InChiKey: TVSLFIQDGTYAIZ-DZXRDFMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (1'R,4'aS,6'aS,10'aS,10'bR)-1'-(methoxymethoxy)-6'a,10'b-dimethylspiro[1,3-dioxolane-2,7'-2,4a,5,6,8,9,10,10a-octahydro-1H-benzo[f]chromene]-3'-one 在 二异丁基氢化铝 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以0.59 g的产率得到
  参考文献：
  名称：

  A Novel Approach to Indoloditerpenes by Nazarov Photocyclization: Synthesis and Biological Investigations of Terpendole E Analogues

  摘要：

  The application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described.

  DOI：

  10.1021/ol100579w
• 作为产物：
  描述：

  、 氯甲基甲基醚 在 二异丙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 以91%的产率得到(1'R,4'aS,6'aS,10'aS,10'bR)-1'-(methoxymethoxy)-6'a,10'b-dimethylspiro[1,3-dioxolane-2,7'-2,4a,5,6,8,9,10,10a-octahydro-1H-benzo[f]chromene]-3'-one
  参考文献：
  名称：

  A Novel Approach to Indoloditerpenes by Nazarov Photocyclization: Synthesis and Biological Investigations of Terpendole E Analogues

  摘要：

  The application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described.

  DOI：

  10.1021/ol100579w

文献信息

• A Novel Approach to Indoloditerpenes by Nazarov Photocyclization: Synthesis and Biological Investigations of Terpendole E Analogues
  作者：Fátima Churruca、Manolis Fousteris、Yuichi Ishikawa、Margarete von Wantoch Rekowski、Candide Hounsou、Thomas Surrey、Athanassios Giannis

  DOI：10.1021/ol100579w

  日期：2010.5.7

  The application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described.