5-fluoro-7-[3-(piperidin-1-ylmethyl)phenyl]quinoxaline | 1225279-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-fluoro-7-[3-(piperidin-1-ylmethyl)phenyl]quinoxaline
• CAS: 1225279-38-8
• 化学式: C₂₀H₂₀FN₃
• 分子量: 321.397
• InChiKey: NKUNZDTVCVNJER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(哌啶-1-甲基)苯硼酸频那醇酯盐酸盐 、 7-溴-5-氟喹噁啉 在 四(三苯基膦)钯 sodium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 0.33h， 生成 5-fluoro-7-[3-(piperidin-1-ylmethyl)phenyl]quinoxaline
  参考文献：
  名称：

  [EN] FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS
  [FR] DÉRIVÉS DE PYRAZINE FUSIONNÉS EN TANT QU'INHIBITEURS DE KINASE

  摘要：

  公开号：

  WO2010052448A3

文献信息

• COMPOSITION FOR FIXING WOUND ITEMS
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2222779A1

  公开（公告）日：2010-09-01
• IMPREGNATING COMPOSITIONS
  申请人：Coatings Foreign IP Co. LLC

  公开号：EP2356162B1

  公开（公告）日：2018-02-14
• Composition for fixing wound items
  申请人：Boehm Frank-Rainer

  公开号：US20090162538A1

  公开（公告）日：2009-06-25

  A composition for fixing wound items comprising A) 0 to 90 wt % of at least one α, β-unsaturated polyester and/or polyester imide resin based on at least one unsaturated mono-, di- or tricarboxylic acids and/or mono-, di- or tricarboxylic acid group containing molecules, at least one polyol and/or, in case of an unsaturated polyester imide, at least one imide having 5-membered cyclic imide moieties, B) 0.1 to 80 wt % of at least one inorganic and/or organic-inorganic hybrid component having functionalities to react with component A) and C), C) 2 to 80 wt % of at least one monomeric and/or oligomeric unsaturated component to react with component A) and B), and D) 0 to 15 wt % of customary additives, the wt % being based on the total weight of the composition. The composition provides excellent thermal transfer properties and a high level of electrical insulation properties with excellent adhesion and thermal stability.
• [EN] COMPOSITION FOR FIXING WOUND ITEMS<br/>[FR] COMPOSITION POUR FIXER DES ARTICLES ENROULÉS
  申请人：DU PONT

  公开号：WO2009085898A1

  公开（公告）日：2009-07-09

  A composition for fixing wound items comprising A) 0 to 90 wt% of at least one α, β-unsaturated polyester and/or polyester imide resin based on at least one unsaturated mono-, di- or tricarboxylic acids and/or mono-, di- or tricarboxylic acid group containing molecules, at least one polyol and/or, in case of an unsaturated polyester imide, at least one imide having 5-membered cyclic imide moieties, B) 0.1 to 80 wt% of at least one inorganic and/or organic-inorganic hybrid component having functionalities to react with component A) and C), C) 2 to 80 wt% of at least one monomeric and/or oligomeric unsaturated component to react with component A) and B), and D) 0 to 15 wt% of customary additives, the wt% being based on the total weight of the composition. The composition provides excellent thermal transfer properties and a high level of electrical insulation properties with excellent adhesion and thermal stability.
• [EN] FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZINE FUSIONNÉS EN TANT QU'INHIBITEURS DE KINASE
  申请人：UCB PHARMA SA

  公开号：WO2010052448A3

  公开（公告）日：2010-09-10