(+/-)-3-[2-(6-trifluoromethylpyrazin)yl]-1-azabicyclo[2.2.2]octane | 141493-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: (+/-)-3-[2-(6-trifluoromethylpyrazin)yl]-1-azabicyclo[2.2.2]octane
• 英文别名: 3-[6-(Trifluoromethyl)pyrazin-2-yl]-1-azabicyclo[2.2.2]octane
• CAS: 141493-00-7
• 化学式: C₁₂H₁₄F₃N₃
• 分子量: 257.258
• InChiKey: WRDQQKCHWLHMQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• A substituted pyrazine and its salts, compositions containing them and their use in medicine
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0473442A1

  公开（公告）日：1992-03-04

  3(R)-[2-(6-trifluoromethylpyrazin)yl]-1-azabicyclo[2.2.2]octane and its salts, and pharmaceutical formulations thereof are useful in medicine. In particular, they are useful for the treatment of neurological and mental illnesses whose clinical manifestations are due to cholinergic dificiency, and for lowering intraocular pressure. The compound may be prepared by dehydroxylating or decarboxylating the corresponding 3-hydroxy- or carboxy-quinuclidine analogue.

  3(R)-[2-(6-三氟甲基吡嗪)基]-1-氮杂双环[2.2.2]辛烷及其盐类以及其药物配方在医学上具有用途。具体而言，它们用于治疗由胆碱能不足引起的神经和精神疾病，以及降低眼内压。该化合物可通过去氢氧化或去羧化相应的3-羟基或羧基喹啉类似物来制备。
• SCOPOLAMINE FOR THE TREATMENT OF DEPRESSION AND ANXIETY
  申请人：GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP1896025A1

  公开（公告）日：2008-03-12
• Scopolamine for the treatment of depression and anxiety
  申请人：Furey L. Maura

  公开号：US20060270698A1

  公开（公告）日：2006-11-30

  Provided herein are methods and compositions for the treatment of depression and anxiety. The compositions comprise scopolamine, or an analog thereof, and can optionally include one or more psychoactive agents. Further provided is an inhaler comprising scopolamine, or an analog thereof, in a pharmaceutically acceptable carrier.
• US5384408A
  申请人：——

  公开号：US5384408A

  公开（公告）日：1995-01-24
• US8859585B2
  申请人：——

  公开号：US8859585B2

  公开（公告）日：2014-10-14