Coleneuramide | 204200-47-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Coleneuramide
• 英文别名: (2R,4S,5R,6R)-5-acetamido-N-[(3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-4-hydroxy-2-methoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxamide
• CAS: 204200-47-5
• 化学式: C₃₉H₆₈N₂O₈
• 分子量: 693.0
• InChiKey: CHMRTBYTCBDIRG-JQZMMWJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  49
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  158
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• MCC-257 MODULATION OF NEUROGENESIS
  申请人：Barlow Carrolee

  公开号：US20090239834A1

  公开（公告）日：2009-09-24

  The disclosure provides methods and a composition for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis by use of (5-acetamido-N-(5alpha-cholestan-3alpha-yl)-3,5-dideoxy-2-O-methyl-D-glycero-alpha-D-galacto-non-2-ulopyranosonamide(MCC-257). The disclosure also includes methods and a composition for stimulating or activating the formation of new nerve cells based on the application of MCC-257
• [EN] A METHOD OF TREATING A NERVOUS SYSTEM DISORDER BY MODULATION OF NEUROGENESIS WITH MCC-257<br/>[FR] PROCÉDÉ DE TRAITEMENT D'UN TROUBLE DU SYSTÈME NERVEUX PAR MODULATION DE NEUROGENÈSE AVEC MCC-257
  申请人：BRAINCELLS INC

  公开号：WO2009123877A1

  公开（公告）日：2009-10-08

  The disclosure provides methods and a composition for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis by use of (5-acetamido-N-(5alρha-cholestan-3alpha-yl)-3,5-dideoxy-2-O- methyl-D-glycero-alpha-D-galacto-non-2-ulopyranosonamide(MCC-257). The disclosure also includes methods and a composition for stimulating or activating the formation of new nerve cells based on the application of MCC-257.