2-acetyloxybenzoic acid;(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | 182486-40-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-acetyloxybenzoic acid;(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• CAS: 182486-40-4
• 化学式: C31H37FO9
• 分子量: 572.6
• InChiKey: LTNLZOOMRZTCCX-WKSAPEMMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.21
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  158
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• DEVICE FOR REGENERATION OF ARTICULAR CARTILAGE AND OTHER TISSUE
  申请人：KENSEY NASH CORPORATION

  公开号：EP1416977A2

  公开（公告）日：2004-05-12
• RESORBABLE STRUCTURE FOR TREATING AND HEALING OF TISSUE DEFECTS
  申请人：KENSEY NASH CORPORATION

  公开号：EP1521602A1

  公开（公告）日：2005-04-13
• [EN] DEVICE FOR REGENERATION OF ARTICULAR CARTILAGE AND OTHER TISSUE<br/>[FR] DISPOSITIF DE REGENERATION DE CARTILAGES ARTICULAIRES ET D'AUTRES TISSUS
  申请人：KENSEY NASH CORP

  公开号：WO2003008007A2

  公开（公告）日：2003-01-30

  An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure.
• [EN] RESORBABLE STRUCTURE FOR TREATING AND HEALING OF TISSUE DEFECTS<br/>[FR] STRUCTURE RESORBABLE POUR TRAITER ET SOIGNER DES TISSUS DEFECTUEUX
  申请人：KENSEY NASH CORP

  公开号：WO2004006973A1

  公开（公告）日：2004-01-22

  Devices and processes (e.g., improved Plasticized Melt Flow processes (PMF) or improved Phase Separation Polymer Concentration (PSPC), etc.) used to make resorbable and non-resorbable structures for treating and/or healing of tissue defects are disclosed. Among the advantages of using these improved processes are the preservation of molecular weight and the broadening of the processing conditions for temperature sensitive polymers and therapies (e.g. polylactide, polyglycolide, polycaprolactone or Cisplatin, etc.). This reduction in processing temperature, pressure and time can help to preserve the molecular weight and/or integrity of the final product or any additive incorporated therein. Additionally, pore size and shape tailoring can increase the osteoconductive nature of the device.