7,8-dihydro-8-phenyl-6H-[1,3]dioxolo-[4,5-g]chromene | 865103-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7,8-dihydro-8-phenyl-6H-[1,3]dioxolo-[4,5-g]chromene
• 英文别名: 7,8-dihydro-8-phenyl-6H-1,3-dioxalo-4,5-chromene；4-phenyl-6,7-methylendioxychromane；8-phenyl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene
• CAS: 865103-47-5
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.285
• InChiKey: KJDAHUAYJRZVPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESS FOR THE PRODUCTION OF 4-SUBSTITUTED CHROMANES VIA GOLD CATALYSIS
  申请人：Council of Scientific and Industrial Research

  公开号：US20150005514A1

  公开（公告）日：2015-01-01

  Disclosed herein is single step process for the synthesis of 4-aryl substituted chromanes of compound of formula 2 comprising subjecting 3-aryloxy-1-phenylpropan-1-ol of formula 1 to gold(III) chloride-catalyzed intramolecular Friedel-Crafts reaction to obtain 4-aryl substituted chromanes. The invention further discloses novel 4-substituted Chromane compounds.

  本文披露了一种单步合成化合物公式2的4-芳基取代色蒽的方法，包括将化合物公式1的3-芳氧基-1-苯基丙醇经过金（III）氯化物催化的分子内费托合成反应，得到4-芳基取代色蒽。本发明还披露了新颖的4-取代色蒽化合物。
• [EN] PROCESS FOR THE PRODUCTION OF 4-SUBSTITUTED CHROMANES VIA GOLD CATALYSIS<br/>[FR] PROCÉDÉ DE PRODUCTION DE CHROMANES 4-SUBSTITUÉS CATALYSÉ PAR L'OR
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2013088455A1

  公开（公告）日：2013-06-20

  Disclosed herein is single step process for the synthesis of 4-aryl substituted chromanes of compound of formula 2 comprising subjecting 3-aryloxy-l-phenylpropan-l-ol of formula 1 to gold (III) chloride-catalyzed intramolecular Friedel-Crafts reaction to obtain 4-aryl substituted chromanes. The invention further discloses novel 4-substituted Chromane compounds.

  本文公开了一种合成式为2的4-芳基取代色烷的单步过程，包括将式为1的3-芳氧基-1-苯基丙醇经过金（III）氯化物催化的分子内Friedel-Crafts反应，制得4-芳基取代色烷。本发明还公开了新型的4-取代色烷化合物。
• Inhibition of respiratory complex III by ligands that interact with a regulatory switch
  申请人：The Regents of the University of California

  公开号：US11058645B2

  公开（公告）日：2021-07-13

  The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.

  本发明提供了抑制细胞中呼吸复合体 III 的方法。本发明还提供了治疗受试者癌症的方法。
• INHIBITION OF RESPIRATORY COMPLEX III BY LIGANDS THAT INTERACT WITH A REGULATORY SWITCH
  申请人：The Regents of the University of California

  公开号：US20210309617A1

  公开（公告）日：2021-10-07

  The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.
• US9102646B2
  申请人：——

  公开号：US9102646B2

  公开（公告）日：2015-08-11