(Z)-3-[3-(diethylamino)propylamino]-6-hydroxy-1-phenylhex-2-en-1-one | 304679-38-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-3-[3-(diethylamino)propylamino]-6-hydroxy-1-phenylhex-2-en-1-one
• CAS: 304679-38-7
• 化学式: C₁₉H₃₀N₂O₂
• 分子量: 318.459
• InChiKey: GALPWTZRRUUKJE-VLGSPTGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  月桂酰氯 、 (Z)-3-[3-(diethylamino)propylamino]-6-hydroxy-1-phenylhex-2-en-1-one 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以45%的产率得到3-[3-(N,N'-diethylamino)propylamino]-1-phenyl-1,8-dicarbonyl-7-oxa-nonadec-2-ene
  参考文献：
  名称：

  Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents 1

  摘要：

  A new series of compounds belonging to 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones (4-12a-e) have been synthesized and evaluated for antioxidant and hypolipidemic activities. Amongst all the synthesized compounds, seven compounds, namely 5b, 5d, 6a, 8a, 8b, 10b and 11a, exhibit better antioxidant activity than probucol. Two compounds, 56 and 10b, have been evaluated in detail for antioxidant and hypolipidemic activities and show comparable activity profile to that of probucol and guggulipid. From the present study it may be postulated that the mechanism of action of these compounds could be through activation of lecithin cholesterol acyltransferase (LCAT), liver lipolytic activity, increased faecal bile acid secretion and inhibition of hepatic cholesterol biosynthesis. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00159-0
• 作为产物：
  描述：

  1-phenyl-6-hydroxy-1,3-hexanedione 在 三溴化磷 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 (Z)-3-[3-(diethylamino)propylamino]-6-hydroxy-1-phenylhex-2-en-1-one
  参考文献：
  名称：

  Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents 1

  摘要：

  A new series of compounds belonging to 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones (4-12a-e) have been synthesized and evaluated for antioxidant and hypolipidemic activities. Amongst all the synthesized compounds, seven compounds, namely 5b, 5d, 6a, 8a, 8b, 10b and 11a, exhibit better antioxidant activity than probucol. Two compounds, 56 and 10b, have been evaluated in detail for antioxidant and hypolipidemic activities and show comparable activity profile to that of probucol and guggulipid. From the present study it may be postulated that the mechanism of action of these compounds could be through activation of lecithin cholesterol acyltransferase (LCAT), liver lipolytic activity, increased faecal bile acid secretion and inhibition of hepatic cholesterol biosynthesis. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00159-0