potassium;dichloroplatinum;isoquinoline;chloride | 292036-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: potassium;dichloroplatinum;isoquinoline;chloride
• CAS: 292036-16-9
• 化学式: C₉H₇Cl₃NPt*K
• 分子量: 469.699
• InChiKey: YBVCHMBKUOLUIA-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -2.38
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异喹啉 、 potassium tetrachloroplatinate(II) 以 not given 为溶剂， 以25%的产率得到potassium;dichloroplatinum;isoquinoline;chloride
  参考文献：
  名称：

  Pt(II) complexes with different N-donor aromatic ligands for specific inhibition of telomerase

  摘要：

  A number of cis-dichloroplatinum(II) derivatives containing aromatic N-donor ligands such as pyridine and/or 5-substituted isoquinolines have been synthesized and fully characterized, with particular use of Raman spectroscopy and mass spectrometry. These complexes have been tested for specific inhibition of telomerase, which could represent a selective target for cancer chemotherapy. The screening of such potential drugs has been performed by a biochemical assay on the isolated enzyme, It is noteworthy that the cis -[PtCl2(pyridine)(5-SO3H-isoquinoline)] compound exhibited remarkable telomerase inhibition at a concentration as low as 10(-7) M. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0020-1693(00)00114-6