7-甲基-3,5-二氢吡咯并[2,3-e]嘧啶-4-酮 | 71435-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 中文名称: 7-甲基-3,5-二氢吡咯并[2,3-e]嘧啶-4-酮
• 英文名称: 7-Methyl-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidin
• 英文别名: 7-methyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one；7-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol；7-methyl-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
• CAS: 71435-37-5
• 化学式: C₇H₇N₃O
• mdl: MFCD17018615
• 分子量: 149.152
• InChiKey: AWETXMHQKQROTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  57.2
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] PROCESS FOR PREPARING PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS PHOSPHORAMIDATÉS DE COMPOSÉS NUCLÉOSIDIQUES UTILISABLES EN VUE DU TRAITEMENT D'INFECTIONS VIRALES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014047117A1

  公开（公告）日：2014-03-27

  Processes for the production of nucleoside phosphoramidate compounds having the following Formula I are provided.

  提供生产以下化学式I的核苷酸磷酰胺化合物的工艺。
• [EN] STING MODULATOR COMPOUNDS WITH SULFAMATE LINKAGES, AND METHODS OF MAKING AND USING<br/>[FR] COMPOSÉS MODULATEURS DE STING INCORPORANT DES LIAISONS DE SULFAMATE, ET PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：TAKEDA PHARMACEUTICALS CO

  公开号：WO2019180683A1

  公开（公告）日：2019-09-26

  The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.