4-chloro-2-(7-chloro-(4-diethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol | 1430822-94-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4-chloro-2-(7-chloro-(4-diethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol
• CAS: 1430822-94-8
• 化学式: C₂₁H₁₉Cl₂N₃O₂
• 分子量: 416.307
• InChiKey: QGNOITMOTKRAPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  58.48
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  二乙胺 、 5-氯代水杨醛 、 6-chloro-2-imino-2H-chromene-3-carbonitrile 在 水 作用下， 反应 10.0h， 以90%的产率得到4-chloro-2-(7-chloro-(4-diethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol
  参考文献：
  名称：

  Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives

  摘要：

  A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno [2,3-d] -pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2, 3-d]pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H-bonding of two of the new compounds are reported by X-ray analysis data.

  DOI：

  10.1021/co300141j

文献信息

• Synthesis, Characterization, and Heterogeneous Catalytic Activity of Sulfamic Acid Functionalized Magnetic IRMOF‐3
  作者：Mohammad Mahdi Mostafavi、Farnaz Movahedi

  DOI：10.1002/ejic.201801054

  日期：2019.2.14

  In this work, post‐synthesis modification of Fe3O4/IRMOF‐3 nanocomposite with chlorosulfonic acid groups afforded sulfamic acid‐functionalized magnetic metal‐organic frameworks (Fe3O4/IRMOF‐3/SO3H). Functionalization was followed through FT‐IR, XRD, TGA, BET, FESEM/EDS and elemental analysis. The catalytic efficiency of the as‐prepared nanocomposite was evaluated through one‐pot pseudo four‐component

  在这项工作中，用氯磺酸基团对Fe 3 O 4 / IRMOF-3纳米复合材料进行合成后修饰提供了氨基磺酸官能化的磁性金属有机骨架（Fe 3 O 4 / IRMOF-3 / SO 3H）。通过FT-IR，XRD，TGA，BET，FESEM / EDS和元素分析进行​​功能化。在温和条件下，通过仲胺，丙二腈和水杨醛在EtOH中的一锅假四组分反应，评估了制备的纳米复合材料的催化效率。功能化IRMOF-3的磁化趋势使得可以在使用外部磁场的情况下从反应混合物中轻松倾析，随后催化剂至少可重复使用五次，而不会显着降低催化效率。