3-N',5-N'-bis(3-oxo-4H-quinoxalin-2-yl)-1H-pyrazole-3,5-dicarbohydrazide | 1217128-82-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-N',5-N'-bis(3-oxo-4H-quinoxalin-2-yl)-1H-pyrazole-3,5-dicarbohydrazide
• CAS: 1217128-82-9
• 化学式: C₂₁H₁₆N₁₀O₄
• 分子量: 472.423
• InChiKey: CYJWJOVYKNCIRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  194
• 氢给体数：
  7
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,4-二氢-2,3-喹喔啉二酮单腙 、 1H-吡唑-3,5-二甲酰氯 以 乙醇 为溶剂， 反应 4.0h， 生成 3-N',5-N'-bis(3-oxo-4H-quinoxalin-2-yl)-1H-pyrazole-3,5-dicarbohydrazide
  参考文献：
  名称：

  Synthesis and spectroscopy of Co II , Ni II , Cu II and Zn II complexes derived from 3,5-disubstituted-1 H -pyrazole derivative: A special emphasis on DNA binding and cleavage studies

  摘要：

  A series of novel Co-II, Ni-II, Cu-II and Zn-II complexes of 1H-pyrazole-3,5-dicarboxylic(2'-hydroxy-3'-hydrazinequinoxaline) has been prepared and characterized by the spectral and analytical techniques. Cull ion reacts with the ligand LH3 and forms the complex in one compartment of the ligand whereas, the other compartment remains free. In Co-II, Ni-II and Zn-II complexes both compartments of LH3 are involved in the coordination. DNA binding/cleavage studies were revealed the stronger binding capability of the present Ni-II complex, confirmed by the absorbance, viscometric and gel-electrophoresis studies. Similarly, remaining complexes do the same in the ligand field with lesser binding constants, subsequently, no complex was found to cleave the DNA. Finally, Cu-II complex shows growth inhibitory activity against biogram. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.10.026

文献信息

• Synthesis and spectroscopy of Co II , Ni II , Cu II and Zn II complexes derived from 3,5-disubstituted-1 H -pyrazole derivative: A special emphasis on DNA binding and cleavage studies
  作者：Srinivasa Budagumpi、Naveen V. Kulkarni、Gurunath S. Kurdekar、M.P. Sathisha、Vidyanand K. Revankar

  DOI：10.1016/j.ejmech.2009.10.026

  日期：2010.2

  A series of novel Co-II, Ni-II, Cu-II and Zn-II complexes of 1H-pyrazole-3,5-dicarboxylic(2'-hydroxy-3'-hydrazinequinoxaline) has been prepared and characterized by the spectral and analytical techniques. Cull ion reacts with the ligand LH3 and forms the complex in one compartment of the ligand whereas, the other compartment remains free. In Co-II, Ni-II and Zn-II complexes both compartments of LH3 are involved in the coordination. DNA binding/cleavage studies were revealed the stronger binding capability of the present Ni-II complex, confirmed by the absorbance, viscometric and gel-electrophoresis studies. Similarly, remaining complexes do the same in the ligand field with lesser binding constants, subsequently, no complex was found to cleave the DNA. Finally, Cu-II complex shows growth inhibitory activity against biogram. (C) 2009 Elsevier Masson SAS. All rights reserved.