1-methyl-4-(tetrahydrofuran-2-yl)piperazine | 357916-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-methyl-4-(tetrahydrofuran-2-yl)piperazine
• 英文别名: 1-Methyl-4-(oxolan-2-yl)piperazine
• CAS: 357916-06-4
• 化学式: C₉H₁₈N₂O
• 分子量: 170.255
• InChiKey: UOXKEURWHFVZKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 2,3-二氢呋喃 在 K2Pd(SCN)4 作用下， 反应 12.0h， 以92%的产率得到1-methyl-4-(tetrahydrofuran-2-yl)piperazine
  参考文献：
  名称：

  Palladium-catalyzed addition of R 2 NH to double bonds. Synthesis of α-amino tetrahydrofuran and pyran rings

  摘要：

  Efficient addition of (RRNH)-R-1-N-2 to unsaturated heterocycles has been achieved using palladium catalysts. The methodology was applied to the synthesis of a number of alpha -amino, tetrahydrofurans and pyrans. Nature of amine, ring size and catalyst were found to affect the reaction. Mechanistic aspects of the reactions were explored by deuterium labelling experiments. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00446-x

文献信息

• US8389720B2
  申请人：——

  公开号：US8389720B2

  公开（公告）日：2013-03-05
• [EN] PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS<br/>[FR] DÉRIVÉS PYRAZOLO [1,5 A]PYRIMIDINE EN TANT QUE MODULATEURS D'IRAK 4
  申请人：HOFFMANN LA ROCHE

  公开号：WO2017108723A2

  公开（公告）日：2017-06-29

  Compounds of Formula (0), Formula (I), and Formula (II) and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.
• Palladium-catalyzed addition of R 2 NH to double bonds. Synthesis of α-amino tetrahydrofuran and pyran rings
  作者：Xiaohui Cheng、King Kuok (Mimi) Hii

  DOI：10.1016/s0040-4020(01)00446-x

  日期：2001.6

  Efficient addition of (RRNH)-R-1-N-2 to unsaturated heterocycles has been achieved using palladium catalysts. The methodology was applied to the synthesis of a number of alpha -amino, tetrahydrofurans and pyrans. Nature of amine, ring size and catalyst were found to affect the reaction. Mechanistic aspects of the reactions were explored by deuterium labelling experiments. (C) 2001 Elsevier Science Ltd. All rights reserved.