N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-5-methyl-1,3-oxazole-2-carboxamide | 524697-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-5-methyl-1,3-oxazole-2-carboxamide
• 英文别名: 2-Oxazolecarboxamide, 5-methyl-N-[(3R)-6-methyl-1-azabicyclo[2.2.2]oct-3-yl]-；5-methyl-N-[(3R)-6-methyl-1-azabicyclo[2.2.2]octan-3-yl]-1,3-oxazole-2-carboxamide
• CAS: 524697-92-5
• 化学式: C₁₃H₁₉N₃O₂
• 分子量: 249.313
• InChiKey: VQTFYPCDLSTRID-RFBVYIQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  58.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
  申请人：——

  公开号：US20030207913A1

  公开（公告）日：2003-11-06

  The invention provides compounds of Formula I: Azabicyclo-N(R 1 )—C(═X)—W  Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which &agr;7 is known to be involved.

  这项发明提供了Formula I的化合物： Azabicyclo-N(R1)—C(═X)—W  Formula I 这些化合物可以是药用盐或组合物的形式，或者是它们的消旋混合物，或者是纯对映体。Formula I的化合物在已知涉及α7的药物中是有用的。
• AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1442041A1

  公开（公告）日：2004-08-04
• US6919359B2
  申请人：——

  公开号：US6919359B2

  公开（公告）日：2005-07-19
• [EN] AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE<br/>[FR] COMPOSES HETEROARYLES SUBSTITUES AZABICYCLIQUES POUR LE TRAITEMENT DE MALADIES
  申请人：UPJOHN CO

  公开号：WO2003040147A1

  公开（公告）日：2003-05-15

  The invention provides compounds of Formula (I): Azabicyclo-N(R1)-C(=X)-W These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula (I) are useful in pharmaceuticals in which α7 is known to be involved.