6H-Pyrrolo[2,3-d]pyrimidine | 271-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 6H-Pyrrolo[2,3-d]pyrimidine
• CAS: 271-69-2
• 化学式: C₆H₅N₃
• 分子量: 119.12
• InChiKey: WGKLVRQVFFRLOJ-UHFFFAOYSA-N

物化性质

• 沸点：
  254.2±33.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• NEW BIS-AMIDO PYRIDINES
  申请人：REISER Ulrich

  公开号：US20150057286A1

  公开（公告）日：2015-02-26

  This invention relates to bis-amido pyridines of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R 1 to R 4 have the meanings given in the claims and in the specification.

  这项发明涉及一般式（I）的双酰胺吡啶，其作为SMAC模拟物的用途，含有它们的药物组合物，以及它们作为治疗和/或预防由细胞过度或异常增殖引起的疾病及相关症状（如癌症）的药物的用途。R1至R4基团的含义如索赔和说明书中所述。
• New 6-Alkynyl Pyridine
  申请人：REISER Ulrich

  公开号：US20150057295A1

  公开（公告）日：2015-02-26

  This invention relates to 6-alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R 1 to R 5 have the meanings given in the claims and in the specification.

  这项发明涉及一般式(I)的6-炔基吡啶，其用作SMAC拟体，含有它们的药物组合物，以及它们作为治疗和/或预防由细胞过度或异常增殖引起的疾病及相关症状（如癌症）的药物的用途。R1至R5基团的含义如索赔和说明书中所述。
• US9249151B2
  申请人：——

  公开号：US9249151B2

  公开（公告）日：2016-02-02
• US9278978B2
  申请人：——

  公开号：US9278978B2

  公开（公告）日：2016-03-08