21-Acetoxy-9α-fluor-11β,17α-dihydroxy-pregna-1,4-dien-3,20-dion

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 21-Acetoxy-9α-fluor-11β,17α-dihydroxy-pregna-1,4-dien-3,20-dion
• 英文别名: Isofluprednone acetate；[2-[(9R,10S,11S,13S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
• 化学式: C₂₃H₂₉FO₆
• 分子量: 420.478
• InChiKey: ZOCUOMKMBMEYQV-JORUCDAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] COMPOSITIONS AND METHODS FOR ENHANCING CELLULAR UPTAKE AND INTRACELLULAR DELIVERY OF LIPID PARTICLES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR AMÉLIORER LA CAPTURE CELLULAIRE ET LA DÉLIVRANCE INTRACELLULAIRE DE PARTICULES LIPIDIQUES
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2011036557A1

  公开（公告）日：2011-03-31

  Compositions, methods and compounds useful for enhancing the uptake of a lipid particle b\ a cell are described In particular embodiments, the methods of the invention include contacting a cell with a lipid particle and a compound that binds a Na+/K+ ATPase to enhance uptake of the lipid particle b\ the cell Related compositions useful in practicing methods include lipid particles comprising a conjugated compound that enhances uptake of the lipid particles b\ the cell The methods and compositions are useful in delivering a therapeutic agent to a cell, e g for the treatment of a disease or disorder in a subject