spiro<1,3>dioxolane-5,9'-<9H>-fluorene-2-methanol butanoate | 139730-24-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: spiro<1,3>dioxolane-5,9'-<9H>-fluorene-2-methanol butanoate
• 英文别名: spiro[1,3]dioxolane-5,9'-[9H]-fluorene-2-methanol butanoate
• CAS: 139730-24-8
• 化学式: C₂₀H₂₀O₄
• 分子量: 324.376
• InChiKey: GKYVFSDVNFBDEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.63
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  9-芴酮 在 对甲苯磺酸 作用下， 以 六甲基磷酰三胺 、 甲苯 为溶剂， 反应 1.5h， 生成 spiro<1,3>dioxolane-5,9'-<9H>-fluorene-2-methanol butanoate
  参考文献：
  名称：

  Enzymatic resolution of 2,2-disubstituted-1,3-dioxolane-4-methanol carboxylic esters

  摘要：

  The enantioselectivity of enzymatic hydrolysis of carboxylic esters of various 1,2-ketals of glycerol has been investigated. The influence of the ketal group has been studied. A number of lipases and proteinases have been tested and the best enantioselectivity was obtained with proteinase from Aspergillus oryzae which gave an E-value of 9 with 2,2-dimethyl-1,3-dioxolane-4-methanol butanoate. Variations in the acyl part revealed that butanoyl was optimal. All hydrolysis products have been synthesised in homochiral forms from homochiral starting materials.

  DOI：

  10.1016/s0957-4166(00)82313-7