2-(3,4-dihydro-1H-isoquinolin-2-yl)-3-methoxybenzaldehyde | 1194283-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-(3,4-dihydro-1H-isoquinolin-2-yl)-3-methoxybenzaldehyde
• CAS: 1194283-32-3
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: UHMOOFRGNJPAEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3,4-dihydro-1H-isoquinolin-2-yl)-3-methoxybenzaldehyde 在 1-叔丁基-4,4,4-三(二甲氨基)-2,2-二[三(二甲氨基)-正膦亚基氨基]-2Λ5,4Λ5-连二(磷氮基化合物) 作用下， 以 苯 为溶剂， 以52%的产率得到8-Methoxy-5,6-dihydroindolo[2,1-a]isoquinoline
  参考文献：
  名称：

  A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activity

  摘要：

  Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.057
• 作为产物：
  描述：

  四氢异喹啉 、 2-氟-3-甲氧基苯甲醛 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以42%的产率得到2-(3,4-dihydro-1H-isoquinolin-2-yl)-3-methoxybenzaldehyde
  参考文献：
  名称：

  A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activity

  摘要：

  Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.057

文献信息

• A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activity
  作者：George A. Kraus、Vinayak Gupta、Marian Kohut、Navrozedeep Singh

  DOI：10.1016/j.bmcl.2009.08.057

  日期：2009.10

  Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma. (C) 2009 Elsevier Ltd. All rights reserved.