5α-hydroxy-6β-[3-(4-aminobutylamino)propylamino]cholestan-3β-ol | 1191043-93-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α-hydroxy-6β-[3-(4-aminobutylamino)propylamino]cholestan-3β-ol
• 英文别名: (3S,5R,6R,8S,9S,10R,13R,14S,17R)-6-[3-(4-aminobutylamino)propylamino]-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,5-diol
• CAS: 1191043-93-2
• 化学式: C₃₄H₆₅N₃O₂
• 分子量: 547.909
• InChiKey: IHMUWFNGVXNPJR-QQFOGAIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.5
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl N-[3-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-3,5-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-yl]amino]propyl]-N-[4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以71%的产率得到5α-hydroxy-6β-[3-(4-aminobutylamino)propylamino]cholestan-3β-ol
  参考文献：
  名称：

  Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases

  摘要：

  We describe here the syntheses and the biological properties of new alkylaminooxysterols. Compounds were synthesized through the trans-diaxial aminolysis of 5,6-alpha-epoxysterols with various natural amines including histamine, putrescine, spermidine, or spermine. The regioselective synthesis of these 16 new 5 alpha-hydroxyl-6 beta-aminoalkylsterols is presented. Compounds were first screened for dendrite outgrowth and cytotoxicity in vitro, and two leads were selected and further characterized. 5 alpha-Hydroxy-6 beta-[2-(1-H-imidazol-4-yl)ethylamino]cholestan -3 beta-ol, called dendrogenin A, induced growth control, differentiation, and the death of tumor cell lines representative of various cancers including metastatic melanoma and breast cancer. 5 alpha-hydroxyl-6 beta-[3-(4-aminobutylamino)propylamino]cholest-7-en-3 beta-ol, called dendrogenin B, induced neurite outgrowth on various cell lines, neuronal differentiation in pluripotent cells, and survival of normal neurones at nanomolar concentrations. In summary, we report that two new alkylaminooxysterols, dendrogenin A and dendrogenin B, are the first members of a class of compounds that induce cell differentiation at nanomolar concentrations and represent promising new leads for the treatment of cancer or neurodegenerative diseases.

  DOI：

  10.1021/jm901063e

文献信息

• PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES
  申请人：INSERM (Institut National de la Sante et de la Recherche Medicale)

  公开号：US20140309417A1

  公开（公告）日：2014-10-16

  The present invention relates to a process for the preparation of sterol derivatives comprising the reaction of an α-epoxy compound with an amine in an alcohol comprising 3 to 5 carbon atoms as a solvent.

  本发明涉及一种制备甾醇衍生物的方法，包括在一种含有3至5个碳原子的醇作为溶剂的情况下，将α-环氧化合物与胺反应。
• Sterol derivatives for treating neurosensory hearing loss, and corresponding composition
  申请人：AFFICHEM

  公开号：US10092577B2

  公开（公告）日：2018-10-09

  The invention relates to a composition for preventing bearing loss in subject or for at least partially restoring bearing in a subject having a reduced auditory function. The composition comprises at least one sterol compound inducing neuron differentiation. Said composition is placed in contact with at least part of the cochlea.

  本发明涉及一种用于防止听觉功能减退的受试者丧失听力或至少部分恢复听力的组合物。该组合物包含至少一种诱导神经元分化的甾醇化合物。所述组合物至少与部分耳蜗接触。
• METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS
  申请人：The Rockefeller University

  公开号：EP3402477A2

  公开（公告）日：2018-11-21
• STEROL DERIVATIVES FOR TREATING NEUROSENSORY HEARING LOSS, AND CORRESPONDING COMPOSITION
  申请人：AFFICHEM

  公开号：US20170209465A1

  公开（公告）日：2017-07-27

  The invention relates to a composition for preventing bearing loss in subject or for at least partially restoring bearing in a subject having a reduced auditory function. The composition comprises at least one sterol compound inducing neuron differentiation. Said composition is placed in contact with at least part of the cochlea.
• TREATMENT AND DIAGNOSIS OF CANCER
  申请人：Rgenix, Inc.

  公开号：US20190125745A1

  公开（公告）日：2019-05-02

  This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors for the treatment of cancer.