[2'-(benzylhydroxycarbamoyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl]carbamic acid tert-butyl ester | 1431469-37-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [2'-(benzylhydroxycarbamoyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl]carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[1-[2-[benzyl(hydroxy)carbamoyl]pyridin-4-yl]piperidin-4-yl]carbamate
• CAS: 1431469-37-2
• 化学式: C₂₃H₃₀N₄O₄
• 分子量: 426.516
• InChiKey: VNRZHJAAWXWVRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  95
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
  申请人：F. HOFFMANN-LA ROCHE LTD

  公开号：US20130102600A1

  公开（公告）日：2013-04-25

  The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

  本发明涉及一种具有通式I的化合物，可选地以药物可接受的盐、溶剂化物、多晶型、前药、互变异构体、外消旋体、对映体、非对映体或其混合物的形式，该化合物在治疗、改善或预防病毒性疾病方面有用。此外，还公开了特定的组合疗法。
• Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease
  申请人：F. HOFFMANN-LA ROCHE LTD

  公开号：US20130102601A1

  公开（公告）日：2013-04-25

  The present invention relates to a compound having the general formula II, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

  本发明涉及具有通式II的化合物，可选地以药学上可接受的盐、溶剂合物、多型体、前药、互变异构体、消旋体、对映体或二对映体或其混合物的形式存在，用于治疗、改善或预防病毒性疾病。此外，还披露了特定的联合疗法。
• PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2794616B1

  公开（公告）日：2016-06-29
• Pyrimidin-4-one derivatives and their use in the tratement, amelioration or prevention of a viral disease
  申请人：F. HOFFMANN-LA ROCHE LTD

  公开号：US20160376286A1

  公开（公告）日：2016-12-29

  The present invention relates to a compound having the general formula II, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
• [EN] HETEROARYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE<br/>[FR] DÉRIVÉS D'ACIDE HÉTÉROARYL-HYDROXAMIQUE ET LEUR UTILISATION POUR TRAITER, AMÉLIORER OU PRÉVENIR UNE MALADIE VIRALE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013057251A2

  公开（公告）日：2013-04-25

  The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or dsasiereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.