2-(Pyridin-4-yl)cyclopropan-1-amine | 933712-84-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(Pyridin-4-yl)cyclopropan-1-amine
• 英文别名: 2-pyridin-4-ylcyclopropan-1-amine
• CAS: 933712-84-6
• 化学式: C₈H₁₀N₂
• 分子量: 134.18
• InChiKey: CISQJYJSJIJMML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS<br/>[FR] INHIBITEURS DE KINASE 1 DE RÉGULATION DE SIGNAL D'APOPTOSE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009123986A1

  公开（公告）日：2009-10-08

  The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  本发明涉及具有以下结构的凋亡信号调节激酶1（"ASK1"）抑制化合物（I）；其中变量如本文所定义。该发明还涉及包含这些化合物的药物组合物、试剂盒和制造品；用于制备这些化合物的有用中间体和方法；以及使用这些化合物的方法。
• FLUORINATED CYCLOPROPYLAMINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USERS THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP3431471A1

  公开（公告）日：2019-01-23

  Provided are a compound represented by formula I, a raceme thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutical salt thereof, and a mixture thereof, a preparation method therefor, a pharmaceutical composition comprising the compound, and uses thereof serving as an lysine specific demethylase 1 (LSD1) inhibitor. Provided are uses of the fluorinated cyclopropylamine compound represented by formula I in the treatment of cancers.

  提供一种由式 I 代表的化合物、其外消旋体、其 R-异构体、其 S-异构体、其药用盐和其混合物、其制备方法、包含该化合物的药物组合物以及其作为赖氨酸特异性去甲基化酶 1（LSD1）抑制剂的用途。提供了式 I 所代表的氟化环丙胺化合物在治疗癌症中的用途。
• Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US10836743B2

  公开（公告）日：2020-11-17

  Provided is a fluorinated cyclopropylamine compound represented by formula I, a racemate thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutical salt thereof, and a mixture thereof. Also provided are pharmaceutical compositions containing the compound, a preparation method for the compound, and uses thereof as a lysine specific demethylase 1 (LSD1) inhibitor, and in the treatment of cancers.

  本发明提供了一种由式 I 代表的氟化环丙胺化合物、其外消旋体、其 R-异构体、其 S-异构体、其药用盐以及其混合物。还提供了含有该化合物的药物组合物、该化合物的制备方法，以及其作为赖氨酸特异性去甲基化酶 1（LSD1）抑制剂和治疗癌症的用途。
• JPH06128237A
  申请人：——

  公开号：JPH06128237A

  公开（公告）日：1994-05-10
• FLUORINATED CYCLOPROPYLAMINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20190100507A1

  公开（公告）日：2019-04-04

  Provided is a fluorinated cyclopropylamine compound represented by formula I, a racemate thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutical salt thereof, and a mixture thereof. Also provided are pharmaceutical compositions containing the compound, a preparation method for the compound, and uses thereof as a lysine specific demethylase 1 (LSD1) inhibitor, and in the treatment of cancers.