15-Butoxytricyclo[10.4.0.04,9]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-6-ol | 1191419-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 15-Butoxytricyclo[10.4.0.04,9]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-6-ol
• CAS: 1191419-06-3
• 化学式: C₂₀H₂₀O₂
• 分子量: 292.378
• InChiKey: SPDZJPGIWBMHLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Method for detecting protein-specific glycosylation
  申请人：The Regents of the University of California

  公开号：US11041850B2

  公开（公告）日：2021-06-22

  Methods are provided for detecting a glycosylated target protein in a sample. Aspects of the methods include: (a) contacting a sample comprising a probe-labeled glycosylated target protein with: (i) a first conjugate comprising a first nucleic acid tag linked to a first capture agent that specifically binds the target protein; (ii) a second conjugate comprising a second nucleic acid tag linked to a second capture agent that specifically binds the probe; and (iii) a bridging nucleic acid that hybridizes to the first and second nucleic acid tags; under conditions sufficient to specifically bind the first and second capture agents to the probe-labeled target protein and to hybridize the bridging nucleic acid to the first and second nucleic acid tags to produce a nucleic acid complex; and (b) detecting the nucleic acid complex. Also provided are compositions and kits useful in practicing various embodiments of the subject methods.

  提供了检测样品中糖基化目标蛋白质的方法。方法的各个方面包括(a) 将包含探针标记的糖基化目标蛋白的样品与以下物质接触：(i) 第一共轭物，包括与第一捕获剂连接的第一核酸标签，第一捕获剂特异性结合目标蛋白；(ii) 第二共轭物，包括与第二捕获剂连接的第二核酸标签，第二捕获剂特异性结合探针；以及 (iii) 桥接核酸，桥接核酸与第一和第二核酸标签杂交；在足以使第一和第二捕获剂与探针标记的靶蛋白特异性结合并使桥接核酸与第一和第二核酸标签杂交以产生核酸复合物的条件下；以及 (b) 检测核酸复合物。此外，还提供了用于实施本主题方法各种实施方案的组合物和试剂盒。
• Chemoselective modification of a carrier protein with a strained alkyne-labeled cargo agent
  申请人：The Regents of the University of California

  公开号：US11135299B2

  公开（公告）日：2021-10-05

  Pharmaceutical compositions are provided for extending the serum half-life of a therapeutic agent. The composition may include a strained alkyne-labeled therapeutic agent. Also provided is a strained alkyne-carrier protein adduct including a vinyl thioether-linkage to a cysteine residue of the carrier protein. Methods of chemoselectively modifying a carrier protein are provided, that include conjugating a cysteine residue of a carrier protein with a cyclooctyne-labeled cargo agent to produce a vinyl thioether-linked conjugate. Also provided is a method of increasing the in vivo half-life of a bioactive agent including administering a strained alkyne-labeled bioactive agent to a subject.

  提供了用于延长治疗剂血清半衰期的药物组合物。该组合物可包括一种经过拉伸的炔烃标记的治疗剂。此外，还提供了一种含乙烯基硫醚连接载体蛋白半胱氨酸残基的受约束炔烃-载体蛋白加合物。提供了化学选择性修饰载体蛋白的方法，其中包括将载体蛋白的半胱氨酸残基与环辛炔标记的货物制剂共轭，生成乙烯基硫醚连接的共轭物。此外，还提供了一种增加生物活性剂体内半衰期的方法，包括向受试者施用经拉伸的炔类标记生物活性剂。
• CHEMOSELECTIVE MODIFICATION OF A CARRIER PROTEIN WITH A STRAINED ALKYNE-LABELED CARGO AGENT
  申请人：The Regents of the University of California

  公开号：US20180147288A1

  公开（公告）日：2018-05-31

  Pharmaceutical compositions are provided for extending the serum half-life of a therapeutic agent. The composition may include a strained alkyne-labeled therapeutic agent. Also provided is a strained alkyne-carrier protein adduct including a vinyl thioether-linkage to a cysteine residue of the carrier protein. Methods of chemoselectively modifying a carrier protein are provided, that include conjugating a cysteine residue of a carrier protein with a cyclooctyne-labeled cargo agent to produce a vinyl thioether-linked conjugate. Also provided is a method of increasing the in vivo half-life of a bioactive agent including administering a strained alkyne-labeled bioactive agent to a subject.
• METHOD FOR DETECTING PROTEIN-SPECIFIC GLYCOSYLATION
  申请人：The Regents of the University of California

  公开号：US20180203000A1

  公开（公告）日：2018-07-19

  Methods are provided for detecting a glycosylated target protein in a sample. Aspects of the methods include: (a) contacting a sample comprising a probe-labeled glycosylated target protein with: (i) a first conjugate comprising a first nucleic acid tag linked to a first capture agent that specifically binds the target protein; (ii) a second conjugate comprising a second nucleic acid tag linked to a second capture agent that specifically binds the probe; and (iii) a bridging nucleic acid that hybridizes to the first and second nucleic acid tags; under conditions sufficient to specifically bind the first and second capture agents to the probe-labeled target protein and to hybridize the bridging nucleic acid to the first and second nucleic acid tags to produce a nucleic acid complex; and (b) detecting the nucleic acid complex. Also provided are compositions and kits useful in practicing various embodiments of the subject methods.