| 1609367-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1609367-89-6
• 化学式: C₁₀₀H₁₈₈N₂₇O₈
• 分子量: 1896.77
• InChiKey: WYAPDMKGWBAKRF-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.12
• 重原子数：
  135.0
• 可旋转键数：
  91.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  484.82
• 氢给体数：
  19.0
• 氢受体数：
  27.0

反应信息

• 作为产物：
  描述：

  、 罗丹明B 在 Rink amide resin 、 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 、 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以1.4%的产率得到
  参考文献：
  名称：

  Cell-penetrating peptoids: Introduction of novel cationic side chains

  摘要：

  During the last decade peptoid-based molecular transporters have been broadly applied. They are highly valued for their easy synthesis and their superior stability against enzymatic degradation. The special structure of peptoids generally allows introducing a variety of different side chains. Yet, the cationic side chains of cell-penetrating peptoids displayed solely lysine- or arginine-like structures. Thus this report is intended to extend the spectrum of cationic peptoid side chains. Herein, we present novel functional groups, like polyamines, aza-crown ethers, or triphenylphosphonium ions that are introduced into peptoids for the first time. In addition, the obtained peptoids were tested for their cell-penetrating properties. (c) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.03.078