4-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride | 745812-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 4-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride
• 英文别名: 4-Chloro-10-methyl-[1,3]benzothiazolo[3,2-a]quinolin-12-ium;chloride
• CAS: 745812-91-3
• 化学式: C₁₆H₁₁ClNS*Cl
• 分子量: 320.242
• InChiKey: AZKOTEUBMWTZHL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.76
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-4-methyl-2-(2,6-dichiorostyryl)benzothiazole 以 1,4-二氧六环 为溶剂， 以65%的产率得到4-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride
  参考文献：
  名称：

  [EN] METHOD FOR PRODUCING BENZAZOLOQUINOLIUM (BQS) SALTS AND USING THE BIOLOGICAL ACTIVITY OF THE COMPOSITION
  [FR] PROCÉDÉ DE PRODUCTION DE SELS BENZAZOLOQUINOLIUM (BQS) ET UTILISATION DE L'ACTIVITÉ BIOLOGIQUE DE LA COMPOSITION

  摘要：

  公开号：

  WO2016044636A3

文献信息

• Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition
  申请人：Sistema Universitario Ana G. Mendez, Inc.

  公开号：US20170079973A1

  公开（公告）日：2017-03-23

  Disclosed is the synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds. The compounds are further used as markers due to their fluorescent properties including in hypoxic environments. This disclosure further describes anti-cancer screening of two BQS, namely, 7-benzyl-3-aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) and the corresponding 7-benzyl-3-nitrobenzimidazo[3,2-a]quinolinium chloride (NBQ 48: NSC D-763303).

  本文披露了苯并咔唑[3,2-a]喹啉盐的合成过程，以及氯取代基、氨基取代基和硝基取代基的加入，从而产生多种化合物。由于它们在低氧环境中的荧光特性，这些化合物进一步被用作标记物。本披露还描述了两种BQS的抗癌筛选，即7-苄基-3-氨基苯并咔唑[3,2-a]喹啉盐（ABQ-48: NSC D-763307）和相应的7-苄基-3-硝基苯并咔唑[3,2-a]喹啉盐（NBQ 48: NSC D-763303）。
• Method for producing benzazoloquinolium (BQs) salts, using the composition as cellular markers, and using the biological activity of the composition
  申请人：Zayas Beatriz

  公开号：US20120129882A1

  公开（公告）日：2012-05-24

  A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage, cellular organelles binding and damage, DNA fragmentation, marker of bacterial growth, antibacterial activity, cell cycle disruption, and a marker due to the auto-fluorescent properties.
• METHOD FOR PRODUCING BENZAZOLOQUINOLIUM (BQS) SALTS AND USING THE BIOLOGICAL ACTIVITY OF THE COMPOSITION
  申请人：Sistema Universitario Ana G. Mendez, Inc.

  公开号：US20180008590A9

  公开（公告）日：2018-01-11

  Disclosed is the synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds. The compounds are further used as markers due to their fluorescent properties including in hypoxic environments. This disclosure further describes anti-cancer screening of two BQS, namely, 7-benzyl-3-aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) and the corresponding 7-benzyl-3-nitrobenzimidazo[3,2-a]quinolinium chloride (NBQ 48: NSC D-763303).
• US9085574B2
  申请人：——

  公开号：US9085574B2

  公开（公告）日：2015-07-21
• US9889128B2
  申请人：——

  公开号：US9889128B2

  公开（公告）日：2018-02-13