2-(furan-2-yl)-ethylamine hydrochloride | 86423-58-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(furan-2-yl)-ethylamine hydrochloride
• 英文别名: 2-furanethaneamine hydrochloride；2-[2]furyl-ethylamine; hydrochloride；2-[2]Furyl-aethylamin; Hydrochlorid；2-(2-Furyl)ethanamine hydrochloride；2-(furan-2-yl)ethanamine;hydrochloride
• CAS: 86423-58-7
• 化学式: C₆H₉NO*ClH
• mdl: MFCD22207169
• 分子量: 147.605
• InChiKey: WDQHIUNKANIJFJ-UHFFFAOYSA-N

物化性质

• 熔点：
  144-146 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.22
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  39.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(6-oxo-5,6,7,8-tetrahydro-[1]naphthyl)-acetamide 、 多巴胺 、 2-(furan-2-yl)-ethylamine hydrochloride 生成 5-Acetylamino-2-[2-(2-furyl)-ethyl-amino]-tetralinehydrochloride
  参考文献：
  名称：

  Method of treating disorders of the dopaminergic systems using

  摘要：

  本发明涉及一种新颖的2,5-二氨基四氢咔啉化合物，其化学式如下：##STR1## 其中R1、R2、R3和R4定义如下，以及制备它们的过程和它们在制药组合物中的应用。这些新颖的2,5-二氨基四氢咔啉化合物在治疗由多巴胺系统紊乱引起的疾病中有用。

  公开号：

  US05196454A1

文献信息

• [EN] PYRROLOPYRAZINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE PYRROLOPYRAZINE KINASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013030138A1

  公开（公告）日：2013-03-07

  The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及式I的新型吡咯并吡嗪衍生物的使用，其中变量如本文所述定义，其抑制JAK和SYK，并可用于治疗自身免疫和炎症性疾病。
• N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted Trp-Phe-
  申请人：Warner-Lambert Company

  公开号：US05622983A1

  公开（公告）日：1997-04-22

  Novel unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.

  本发明涉及一种新颖的非天然二肽类α-取代Trp-Phe衍生物，可用作治疗肥胖症、肠道胃酸过多、胃泌素依赖性肿瘤、结肠癌或作为抗精神病药物。此外，这些化合物还具有抗焦虑、抗溃疡、抗抑郁作用，并可用于预防尼古丁、安定、酒精、可卡因、咖啡因或阿片类药物的长期治疗或使用后出现的戒断反应。本发明还涉及使用这些二肽类化合物制备药物和诊断组合物的方法。同时，本发明还涉及制备这些化合物的方法以及在制备中有用的新型中间体。
• N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe-
  申请人：Warner-Lambert Company

  公开号：US05278316A1

  公开（公告）日：1994-01-11

  Novel unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.

  本发明揭示了一种新型非天然二肽类α-取代Trp-Phe衍生物，可用作治疗肥胖症、肠道中胃酸过多、胃泌素依赖性肿瘤或抗精神病药物。此外，这些化合物还具有抗焦虑、抗溃疡、抗抑郁的作用，并可用于预防尼古丁、地西泮、酒精、可卡因、咖啡因或阿片类药物的慢性治疗或使用后的戒断反应。本发明还揭示了使用这些二肽类化合物制备药物和诊断组合物的方法。同时，还揭示了制备这些化合物的过程和制备中间体的新方法。
• Treatment of pain and colorectal cancer with dipeptoids of
  申请人：Warner-Lambert Company

  公开号：US05580896A1

  公开（公告）日：1996-12-03

  This invention relates to the treatment of pain and inhibiting the growth of colorectal cancer with dipeptoids of .alpha.-substituted Trp-Phe derivatives.

  本发明涉及使用α-取代的Trp-Phe二肽衍生物治疗疼痛和抑制结直肠癌生长。
• Neue 2,5-Diaminotetraline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
  申请人：BOEHRINGER INGELHEIM KG

  公开号：EP0402923A2

  公开（公告）日：1990-12-19

  Die Erfindung betrifft neue 2,5-Diaminotetraline, Verfahren zur ihrer Herstellung und ihre Verwendung als Arzneimittel.

  本发明涉及新的 2,5-二氨基四氢萘，其制备工艺及其作为药物的用途。