N-(2-hydroxyethyl)-2-oxohexadecanamide | 158305-65-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-hydroxyethyl)-2-oxohexadecanamide
• CAS: 158305-65-8
• 化学式: C₁₈H₃₅NO₃
• 分子量: 313.481
• InChiKey: RXELGCSSRFMZCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 N-(2-hydroxyethyl)-2-oxohexadecanamide
  参考文献：
  名称：

  A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity

  摘要：

  A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K-i 21.8 mu M) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.039

文献信息

• A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity
  作者：Victoria Magrioti、George Naxakis、Dimitra Hadjipavlou-Litina、Alexandros Makriyannis、George Kokotos

  DOI：10.1016/j.bmcl.2008.09.039

  日期：2008.10

  A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K-i 21.8 mu M) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain. (C) 2008 Elsevier Ltd. All rights reserved.