3β,12β-dihydroxy-5β-androstane-17β-carboxylic acid | 882982-06-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β,12β-dihydroxy-5β-androstane-17β-carboxylic acid
• 英文别名: 3β,12β-Dihydroxy-5β-androstan-17β-carbonsaeure；3β,12β-Dihydroxy-21-nor-5β-pregnansaeure-(20)；(3S,5R,8R,9S,10S,12R,13S,14S,17S)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid
• CAS: 882982-06-1
• 化学式: C₂₀H₃₂O₄
• 分子量: 336.472
• InChiKey: JQJFMOYALOFIJZ-NXUFLOGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3β,12β-diacetoxy-5β-androstane-17β-carboxylic acid methyl ester 在 氢氧化钾 作用下， 生成 3β,12β-dihydroxy-5β-androstane-17β-carboxylic acid
  参考文献：
  名称：

  Microdialysis study of bromocriptine and its metabolites in rat pituitary and striatum

  摘要：

  Bromocriptine, a D-2 receptor agonist, was administered intravenously (1 mg/kg) to anesthetized rats. Microdialysis probes were implanted in the pituitary and the striatum, known sites of D-2 agonist action. Bromocriptine and its metabolites were monitored in plasma and tissue dialysates for 4 h. Drug analyses were performed using two different enzyme immunoassays specific for untransformed bromocriptine or a pool of parent drug plus hydroxylated metabolites. The metabolites/parent drug ratio for areas under the curve was 5.5 in plasma and 1 in the pituitary. No metabolites could be detected in the striatum. Bromocriptine penetration was at least 10-fold greater in the pituitary than in the striatum. The kinetics of bromocriptine in the pituitary and striatum did not parallel those in plasma, indicating that the prolonged action of bromocriptine reported by other authors may be due to slow dissociation from receptors.

  DOI：

  10.1007/bf03190071

文献信息

• Ein neuer Abbau des Digoxigenins
  作者：M. Steiger、T. Reichstein

  DOI：10.1002/hlca.193802101108

  日期：——