2-[4-(trifluoromethyl)piperidin-1-yl]-5H-spiro[benzo[h]quinazoline-6,4-piperidine] | 1234353-54-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[4-(trifluoromethyl)piperidin-1-yl]-5H-spiro[benzo[h]quinazoline-6,4-piperidine]
• 英文别名: 2-[4-(trifluoromethyl)piperidin-1-yl]spiro[5H-benzo[h]quinazoline-6,4'-piperidine]
• CAS: 1234353-54-8
• 化学式: C₂₂H₂₅F₃N₄
• 分子量: 402.463
• InChiKey: MMKCUUGYLRWTCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  41
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] POLYCYCLIC GUANINE DERIVATIVE PHOSPHODIESTERASE V INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHODIESTERASE V DE DERIVES POLYCYCLIQUES DE GUANINE
  申请人：SCHERING CORP

  公开号：WO2003042216A1

  公开（公告）日：2003-05-22

  A compound having the formula (Ia) or (b), salt or solvate thereof, with the variables as defined herein, which can inhibit selectively phosphodiesterase V and can be useful for treating sexual dysfunction and other physiological disorders, symptoms and diseases

  具有化学式(Ia)或(b)的化合物，其盐或溶剂化物，其中变量的定义如此，可以选择性地抑制磷酸二酯酶V，并可用于治疗性功能障碍和其他生理障碍、症状和疾病。
• SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
  申请人：Ali Syed M.

  公开号：US20100239525A1

  公开（公告）日：2010-09-23

  The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物及其合成方法。本发明还涉及含有取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的药物组合物，以及通过将这些化合物和药物组合物用于需要治疗细胞增殖性疾病的受试者来治疗癌症等细胞增殖性疾病的方法。
• US8357694B2
  申请人：——

  公开号：US8357694B2

  公开（公告）日：2013-01-22
• [EN] SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS DE 5,6-DIHYDRO-6-PHÉNYLBENZO[F]ISOQUINOLÉINE-2-AMINES SUBSTITUÉES
  申请人：ARQULE INC

  公开号：WO2010078421A1

  公开（公告）日：2010-07-08

  The present invention relates to substituted 5,6-dihydro-6- phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.