N-cyclohexyl-2-(2,6-dioxo-piperidin-4-yl)-acetamide | 23762-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-cyclohexyl-2-(2,6-dioxo-piperidin-4-yl)-acetamide
• 英文别名: N-cyclohexyl-2-(2,6-dioxopiperidin-4-yl)acetamide
• CAS: 23762-79-0
• 化学式: C₁₃H₂₀N₂O₃
• 分子量: 252.313
• InChiKey: BJMUYZDTAFJRQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2,6-二氧代-4-哌啶)-乙酸 、 环己胺 在 N-甲基咪唑 、 对甲苯磺酰氯 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以33%的产率得到N-cyclohexyl-2-(2,6-dioxo-piperidin-4-yl)-acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

  摘要：

  Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-kappa B (nuclear factor-kappa B) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.107

文献信息

• Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB
  作者：Yuichi Ishikawa、Miyuki Tachibana、Chino Matsui、Rika Obata、Kazuo Umezawa、Shigeru Nishiyama

  DOI：10.1016/j.bmcl.2009.01.107

  日期：2009.3

  Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-kappa B (nuclear factor-kappa B) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone. (C) 2009 Elsevier Ltd. All rights reserved.