4-[3-(3-methylpiperidin-1-yl)quinoxalin-6-yl]phenol | 1271836-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-[3-(3-methylpiperidin-1-yl)quinoxalin-6-yl]phenol
• CAS: 1271836-58-8
• 化学式: C₂₀H₂₁N₃O
• 分子量: 319.406
• InChiKey: LWGYMGMXFBIEFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS<br/>[FR] AMINOQUINOXALINES SUBSTITUÉES SERVANT D'INHIBITEURS DE TYROSINE-THRÉONINE KINASES
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2011026579A1

  公开（公告）日：2011-03-10

  The present invention relates to substituted aminoquinoxaline compounds of general formula (I) in which (II), R2, R3, R4, R6, R7, n and m are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

  本发明涉及通式（I）中的取代氨基喹喔啉化合物，其中（II）、R2、R3、R4、R6、R7、n和m如描述和权利要求中所述，涉及制备该化合物的方法，包括该化合物的药物组合物和组合物，用于制造治疗或预防疾病的药物组合物的用途，以及用于制备该化合物的中间化合物。
• SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS
  申请人：Bader Benjamin

  公开号：US20120263708A1

  公开（公告）日：2012-10-18

  The present invention relates to substituted aminoquinoxaline compounds of general formula (I) in which (II), R 2 , R 3 , R 4 , R 6 , R 7 , n and m are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

  本发明涉及通式（I）的取代氨基喹喔啉化合物，其中（II），R2，R3，R4，R6，R7，n和m如描述和权利要求中所给出的，涉及制备该化合物的方法，包括该化合物的制药组合物和组合物，以及用于制造用于治疗或预防疾病的制药组合物的该化合物的用途，以及在制备该化合物中有用的中间体化合物。
• US9340528B2
  申请人：——

  公开号：US9340528B2

  公开（公告）日：2016-05-17