(3S,5S,6R)-4-(tert-butoxycarbonyl)-5,6-diphenyl-3-[3'-(4''-methylphenylsulfonyloxy)prop-1'-yl]morpholin-2-one | 1196980-77-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (3S,5S,6R)-4-(tert-butoxycarbonyl)-5,6-diphenyl-3-[3'-(4''-methylphenylsulfonyloxy)prop-1'-yl]morpholin-2-one
• 英文别名: tert-butyl (3S,5S,6R)-3-[3-(4-methylphenyl)sulfonyloxypropyl]-2-oxo-5,6-diphenylmorpholine-4-carboxylate
• CAS: 1196980-77-4
• 化学式: C₃₁H₃₅NO₇S
• 分子量: 565.687
• InChiKey: LNRMZIJZMROACM-HZFUHODCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (3S,5S,6R)-4-(tert-butoxycarbonyl)-5,6-diphenyl-3-[3'-(4''-methylphenylsulfonyloxy)prop-1'-yl]morpholin-2-one 在 三氟乙酸 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.58h， 以91%的产率得到(1S,4R,5S)-6-aza-4,5-diphenyl-2-oxo-3-oxabicyclo[4.3.0]nonane
  参考文献：
  名称：

  Enantioselective Syntheses of α-Fmoc-Pbf-[2-¹³C]-l-arginine and Fmoc-[1,3-¹³C₂]-l-proline and Incorporation into the Neurotensin Receptor 1 Ligand, NT₈₋₁₃

  摘要：

  Enantioselective syntheses of selectively labeled, orthogonally protected [2-C-13]L-arginine and [1,3-C-13(2)]-L-proline are described from the commercially available precursors [2-C-13]bromoacetic acid and potassium [C-13]cyanide, Interestingly the enhanced signal assigned to C-2 in the C-13 NMR spectrum of alpha-Fmoc-Pbf-[2-C-13]-L-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-C-13]-Arg9 and [1,3-C-13(2)]-Pro 10 labeled ligand (NT8-13) by manual Fmoc-SPSS.

  DOI：

  10.1021/jo9014497
• 作为产物：
  描述：

  (3S,5S,6R)-4-(tert-butoxycarbonyl)-5,6-diphenyl-3-(3'-hydroxyprop-1'-yl)morpholin-2-one 、 对甲苯磺酰氯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 27.0h， 以83%的产率得到(3S,5S,6R)-4-(tert-butoxycarbonyl)-5,6-diphenyl-3-[3'-(4''-methylphenylsulfonyloxy)prop-1'-yl]morpholin-2-one
  参考文献：
  名称：

  Enantioselective Syntheses of α-Fmoc-Pbf-[2-¹³C]-l-arginine and Fmoc-[1,3-¹³C₂]-l-proline and Incorporation into the Neurotensin Receptor 1 Ligand, NT₈₋₁₃

  摘要：

  Enantioselective syntheses of selectively labeled, orthogonally protected [2-C-13]L-arginine and [1,3-C-13(2)]-L-proline are described from the commercially available precursors [2-C-13]bromoacetic acid and potassium [C-13]cyanide, Interestingly the enhanced signal assigned to C-2 in the C-13 NMR spectrum of alpha-Fmoc-Pbf-[2-C-13]-L-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-C-13]-Arg9 and [1,3-C-13(2)]-Pro 10 labeled ligand (NT8-13) by manual Fmoc-SPSS.

  DOI：

  10.1021/jo9014497

文献信息

• Enantioselective Syntheses of α-Fmoc-Pbf-[2-¹³C]-<scp>l</scp>-arginine and Fmoc-[1,3-¹³C₂]-<scp>l</scp>-proline and Incorporation into the Neurotensin Receptor 1 Ligand, NT₈₋₁₃
  作者：Chuanjun Song、Satita Tapaneeyakorn、Annabel C. Murphy、Craig Butts、Anthony Watts、Christine L. Willis

  DOI：10.1021/jo9014497

  日期：2009.12.4

  Enantioselective syntheses of selectively labeled, orthogonally protected [2-C-13]L-arginine and [1,3-C-13(2)]-L-proline are described from the commercially available precursors [2-C-13]bromoacetic acid and potassium [C-13]cyanide, Interestingly the enhanced signal assigned to C-2 in the C-13 NMR spectrum of alpha-Fmoc-Pbf-[2-C-13]-L-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-C-13]-Arg9 and [1,3-C-13(2)]-Pro 10 labeled ligand (NT8-13) by manual Fmoc-SPSS.