1-(2,4-difluorophenyl)-6-fluoro-7-[(2,8-diazabicyclo[4.3.0]non-5-en)-8-yl]-4-oxo-1,8-naphthyridine-3-carboxylic Acid | 160589-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-(2,4-difluorophenyl)-6-fluoro-7-[(2,8-diazabicyclo[4.3.0]non-5-en)-8-yl]-4-oxo-1,8-naphthyridine-3-carboxylic Acid
• 英文别名: 7-(1,2,3,5,7,7a-Hexahydropyrrolo[3,4-b]pyridin-6-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• CAS: 160589-12-8
• 化学式: C₂₂H₁₇F₃N₄O₃
• 分子量: 442.397
• InChiKey: HDYGMQGLHYMHGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Novel quinolone carboxylic acid derivatives and process for preparing the same
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP0622367A1

  公开（公告）日：1994-11-02

  The present invention relates to novel quinolone carboxylic acid derivatives of formula (I): wherein, R₁, R₂ and R3, which may be the same or different, are each hydrogen or a halogen atom, or a lower alkyl group or a lower alkyl group substituted with an amino or hydroxy group; R₄ is hydrogen atom, a lower alkyl, benzyl, t-butoxycarbonyl or ethoxycarbonyl group; R₅ is hydrogen, chlorine atom, methyl or an amino group; R₆ is a lower alkyl group, or a cyclopropyl or a phenyl group optionally substituted with a halogen atom; and X is nitrogen atom, or a methyne group optionally substituted with a lower alkyl or a lower alkoxy group or a halogen atom, and pharmaceutically acceptable salts thereof, and processes for preparing these compounds. The present invention also relates to novel intermediates which are useful for preparing the quinolone compounds of the invention. The novel quinolone carboxylic acid derivatives of the present invention have a broad spectrum of potent antibacterial activities against various microorganisms.

  本发明涉及公式（I）的新型喹诺酮羧酸衍生物： 其中，R₁、R₂和R₃可以相同也可以不同，分别是氢原子或卤素原子，或者是取代有氨基或羟基的较低烷基基团； R₄是氢原子、较低烷基、苄基、叔丁氧羰基或乙氧羰基基团； R₅是氢、氯原子、甲基或氨基基团； R₆是较低烷基基团，或者是取代有卤素原子的环丙基或苯基基团；X是氮原子，或者是取代有较低烷基或较低烷氧基或卤素原子的甲烷基团，以及其药学上可接受的盐，并且制备这些化合物的方法。本发明还涉及用于制备本发明喹诺酮化合物的新型中间体。本发明的新型喹诺酮羧酸衍生物具有广谱的抗菌活性，对各种微生物具有强大的抗菌活性。
• US5498615A
  申请人：——

  公开号：US5498615A

  公开（公告）日：1996-03-12
• US5631266A
  申请人：——

  公开号：US5631266A

  公开（公告）日：1997-05-20