1-((2,3-difluorophenyl)(piperidin-1-yl)methyl)naphthalen-2-ol | 1393729-43-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-((2,3-difluorophenyl)(piperidin-1-yl)methyl)naphthalen-2-ol
• 英文别名: 1-[(2,3-Difluorophenyl)-piperidin-1-ylmethyl]naphthalen-2-ol
• CAS: 1393729-43-5
• 化学式: C₂₂H₂₁F₂NO
• 分子量: 353.412
• InChiKey: VMLIBDLNKPPSQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  哌啶 、 2,3-二氟苯甲醛 、 2-萘酚 在 solid phase supported copper(II) triflate 作用下， 反应 1.33h， 以90%的产率得到1-((2,3-difluorophenyl)(piperidin-1-yl)methyl)naphthalen-2-ol
  参考文献：
  名称：

  Supported copper triflate as an efficient catalytic system for the synthesis of highly functionalized 2-naphthol Mannich bases under solvent free condition

  摘要：

  Various heterogeneous catalysts (Lewis acid) have been prepared and screened for the synthesis of Betti bases in an attempt to reduce the environmental hazards associated with the conventional homogeneous Lewis acid system. And we found especially Cu(OTf)(2)center dot SiO2 catalyzes the three-component coupling of aldehyde, 2-naphthol, and alicyclic amine to generate Betti base with high efficiency under neat conditions without additional co-catalyst or additive in air. The reaction is not sensitive to water and occurs smoothly in water as well. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.022