2-ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid (1-methyl-butyl)-amide | 1432747-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-ethyl-6,7-dimethoxy-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid (1-methyl-butyl)-amide
• 英文别名: US9856220, Example 15；2-ethyl-6,7-dimethoxy-1-oxo-N-pentan-2-ylisoquinoline-4-carboxamide
• CAS: 1432747-42-6
• 化学式: C₁₉H₂₆N₂O₄
• 分子量: 346.426
• InChiKey: JPGZIRAMHLFJKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• HETEROCYCLIC CARBOXAMIDES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE TYPE 10A
  申请人：Abbvie Deutschland GmbH & Co. KG

  公开号：EP2780324A1

  公开（公告）日：2014-09-24
• [EN] HETEROCYCLIC CARBOXAMIDES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE TYPE 10A<br/>[FR] CARBOXAMIDES HÉTÉROCYCLIQUES UTILES COMME INHIBITEURS DE LA PHOSPHODIESTÉRASE DE TYPE 10A
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2013068489A1

  公开（公告）日：2013-05-16

  Novel inhibitor compounds of phosphodiesterase type 10A The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.