5-fluoro-N-(2-methyl-1,3-benzothiazol-5-yl)-2-((1H-pyrazolo[3,4-b]pyridin-4-ylmethyl)amino)-3-pyridinecarboxamide | 935466-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 5-fluoro-N-(2-methyl-1,3-benzothiazol-5-yl)-2-((1H-pyrazolo[3,4-b]pyridin-4-ylmethyl)amino)-3-pyridinecarboxamide
• 英文别名: 5-fluoro-N-(2-methyl-1,3-benzothiazol-5-yl)-2-(1H-pyrazolo[3,4-b]pyridin-4-ylmethylamino)pyridine-3-carboxamide
• CAS: 935466-44-7
• 化学式: C₂₁H₁₆FN₇OS
• 分子量: 433.469
• InChiKey: HOLLNCGUGYFOQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Compounds and methods of use
  申请人：Germain Julie

  公开号：US20070185171A1

  公开（公告）日：2007-08-09

  Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗血管生成介导的疾病等疾病有效。该发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的盐、药物组合物以及预防和治疗癌症等涉及疾病和其他疾病或病况的方法。该发明还涉及制造这种化合物的过程以及在这种过程中有用的中间体。
• PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES
  申请人：Amgen Inc.

  公开号：EP1971604A2

  公开（公告）日：2008-09-24
• US8247556B2
  申请人：——

  公开号：US8247556B2

  公开（公告）日：2012-08-21
• [EN] COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS ET MÉTHODES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2007048070A2

  公开（公告）日：2007-04-26

  [EN] Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
  [FR] L'invention concerne des composés sélectionnés efficaces dans le traitement prophylactique et thérapeutique de maladies, par exemple de maladies faisant intervenir l'angiogenèse. La présente invention englobe les nouveaux composés, les analogues, les promédicaments et les sels de qualité pharmaceutique desdits composés, les préparations pharmaceutiques et les méthodes de traitement prophylactique et thérapeutique de maladies et autres affections ou états pathologiques liés au cancer, entre autres. La présente invention concerne également des procédés de fabrication de tels composés, ainsi que des intermédiaires pouvant être employés dans de tels procédés.