4-[8-(Cyclopentylmethyl-methyl-amino)-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino]-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide | 1192166-53-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 4-[8-(Cyclopentylmethyl-methyl-amino)-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino]-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide
• 英文别名: 4-[[8-[cyclopentylmethyl(methyl)amino]-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
• CAS: 1192166-53-2
• 化学式: C₃₀H₄₄N₈O₃
• 分子量: 564.731
• InChiKey: ZIHHAMLUMKRHLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Dihydropteridinones as Plk Inhibitors
  申请人：GPC Biotech AG

  公开号：EP2112152A1

  公开（公告）日：2009-10-28

  The present invention provides derivatives of dihydropteridinone of formula (I). These compounds are inhibitors of Polo-like kinases (Plks), including compounds that show anti-proliferative activity against cells, including against tumor cells, and are useful in the treatment of diseases including cancer.

  本发明提供了公式（I）的二氢叶酸酮衍生物。这些化合物是波洛样激酶（Plks）的抑制剂，包括对细胞具有抗增殖活性的化合物，包括对肿瘤细胞的抗活性，并且在治疗包括癌症在内的疾病中是有用的。
• [EN] DIHYDROPTERIDINONES AS PLK INHIBITORS<br/>[FR] DIHYDROPTÉRIDINONES COMME INHIBITEURS DE PLK
  申请人：GPC BIOTECH AG

  公开号：WO2009130016A1

  公开（公告）日：2009-10-29

  The present invention provides derivatives of dihydropteridione of formula (I). These compounds are inhibitors of Polo-like kinases (Plks), including compounds that show antiproliferative activity against cells, including against tumor cells, and are useful in the treatment of diseases including cancer.