3β-hydroxy-5-methyl-19-nor-5β,9β,10β-androstan-17β-yl cyclohexanecarboxylate | 402713-59-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-hydroxy-5-methyl-19-nor-5β,9β,10β-androstan-17β-yl cyclohexanecarboxylate
• CAS: 402713-59-1
• 化学式: C₂₆H₄₂O₃
• 分子量: 402.618
• InChiKey: GVFQWRVDZIYLHV-SFESNHAHSA-N

反应信息

• 作为反应物：
  描述：

  3β-hydroxy-5-methyl-19-nor-5β,9β,10β-androstan-17β-yl cyclohexanecarboxylate 在 jones reagent 作用下， 以 丙酮 为溶剂， 反应 0.17h， 以91%的产率得到3-oxo-5-methyl-19-nor-5β,9β,10β-androstan-17β-yl cyclohexanecarboxylate
  参考文献：
  名称：

  Analogues of androgen hormones with inverted configuration at carbons 5, 9, and 10

  摘要：

  On catalytic hydrogenation of Delta (9)-steroids (e.g. 3 beta -hydroxy-5-methyl-19-nor-5 beta -androst-9-en-17-one), four isomers were formed: 9 alpha ,10 alpha-, 9 alpha ,10 beta-, 9 beta ,10 alpha- and 9 beta ,10 beta -adducts. The product distribution was affected by the nature of the C-3 substituent. A chair conformation of A, B, and C rings was found in all of the products with the exception of the 9 alpha ,10 alpha -adduct whose B ring adopts a twist boat conformation. The products were utilized for the synthesis of dihydrotestosterone analogues. (C) 2002 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(01)00135-0
• 作为产物：
  描述：

  5-methyl-19-nor-3-oxo-5β-androst-9-en-17β-yl benzoate 在 platinum(IV) oxide sodium tetrahydroborate 、 氢气 作用下， 以 乙醇 、 二氯甲烷 、 溶剂黄146 为溶剂， 反应 19.0h， 生成 3β-hydroxy-5-methyl-19-nor-5β,9β,10β-androstan-17β-yl cyclohexanecarboxylate
  参考文献：
  名称：

  Analogues of androgen hormones with inverted configuration at carbons 5, 9, and 10

  摘要：

  On catalytic hydrogenation of Delta (9)-steroids (e.g. 3 beta -hydroxy-5-methyl-19-nor-5 beta -androst-9-en-17-one), four isomers were formed: 9 alpha ,10 alpha-, 9 alpha ,10 beta-, 9 beta ,10 alpha- and 9 beta ,10 beta -adducts. The product distribution was affected by the nature of the C-3 substituent. A chair conformation of A, B, and C rings was found in all of the products with the exception of the 9 alpha ,10 alpha -adduct whose B ring adopts a twist boat conformation. The products were utilized for the synthesis of dihydrotestosterone analogues. (C) 2002 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(01)00135-0