N-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-2-((5-methylfuran-2-yl)methylene)hydrazine-1-carboxamide | 1374975-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-2-((5-methylfuran-2-yl)methylene)hydrazine-1-carboxamide
• CAS: 1374975-42-4
• 化学式: C₂₂H₁₇ClN₄O₄
• 分子量: 436.854
• InChiKey: SLVXSBNCXZQPDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.13
• 重原子数：
  31.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  104.01
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  5-amino-1-(4-chlorobenzyl)indoline-2,3-dione 在 一水合肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 N-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-2-((5-methylfuran-2-yl)methylene)hydrazine-1-carboxamide
  参考文献：
  名称：

  Design and synthesis of 4-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-1-(4-substituted/unsubstituted benzylidene) semicarbazide: Novel agents with analgesic, anti-inflammatory and ulcerogenic properties

  摘要：

  A new series of isatin semicarbazide derivatives (7a-7j) were synthesized and characterized by spectroscopic means and elemental analysis. Analgesic and anti-inflammatory screening was performed using tail-flick technique and the carrageenan-induced foot paw edema test respectively. The ulcerogenicity was also determined for all the compounds. Some of the compounds showed moderate enhancement of the activity. Among the synthesized derivatives, compound 7d showed higher analgesic, antiinflammatory and one-third of ulcer index of the reference drug. (C) 2012 Chinnasamy Rajaram Prakash. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.03.014