N-{3,10-dithia-5,12-diazatricyclo[7.3.0.0^2,6]dodeca-1,4,6,8,11-pentaen-4-yl}-2H-1,3-benzodioxole-5-carboxamide | 1428729-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-{3,10-dithia-5,12-diazatricyclo[7.3.0.0^2,6]dodeca-1,4,6,8,11-pentaen-4-yl}-2H-1,3-benzodioxole-5-carboxamide
• 英文别名: N-([1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-1,3-benzodioxole-5-carboxamide
• CAS: 1428729-58-1
• 化学式: C₁₆H₉N₃O₃S₂
• 分子量: 355.398
• InChiKey: NBRLINMOISSQBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ANTI-VIRAL COMPOUNDS
  申请人：Kineta, Inc.

  公开号：EP2748172B1

  公开（公告）日：2017-12-06
• ANTI-VIRAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
  申请人：Kineta, Inc.

  公开号：US20170057978A1

  公开（公告）日：2017-03-02

  Disclosed herein are compounds, pharmaceutical compositions, and related methods for the treatment of viral infection, including RNA viral infection in subjects. The compounds, pharmaceutical compositions, and methods can modulate the innate immune antiviral response in vertebrate cells, including activating the RIG-I pathway.
• US9884876B2
  申请人：——

  公开号：US9884876B2

  公开（公告）日：2018-02-06
• [EN] ANTI-VIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTI-VIRAUX
  申请人：KINETA INC

  公开号：WO2013049407A2

  公开（公告）日：2013-04-04

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.