6-(pentyloxy)-1-(4-(pyridin-3-yl)thiazol-2-yl)quinoxaline-2,3(1H,4H)-dione | 949118-81-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(pentyloxy)-1-(4-(pyridin-3-yl)thiazol-2-yl)quinoxaline-2,3(1H,4H)-dione
• 英文别名: 7-pentoxy-4-[4-(3-pyridyl)thiazol-2-yl]-1H-quinoxaline-2,3-dione；7-pentoxy-4-(4-pyridin-3-yl-1,3-thiazol-2-yl)-1H-quinoxaline-2,3-dione
• CAS: 949118-81-4
• 化学式: C₂₁H₂₀N₄O₃S
• 分子量: 408.481
• InChiKey: TZQATHBODCHBFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Substituted Aminothiazole Derivatives With Anti-HCV Activity
  申请人：Zhang Souming

  公开号：US20070213301A1

  公开（公告）日：2007-09-13

  The invention provides amino-substituted aminothiazole compounds of Formula I in which A is a group of the formula: and the variables R and R 1 to R 7 are described herein. These compounds are useful as inhibitors of viral replication. Compositions containing such compounds, and methods of treating viral infections with these compounds, as well as to processes and intermediates useful for preparing such compounds are also provided by the invention.

  该发明提供了公式I中的氨基取代氨噻唑化合物，其中A是以下式子的基团：变量R和R1至R7如下所述。这些化合物可用作病毒复制的抑制剂。本发明还提供了含有这些化合物的组合物，以及使用这些化合物治疗病毒感染的方法，以及用于制备这些化合物的过程和中间体。
• Substituted aminothiazole derivatives with anti-HCV activity
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：EP2460800A1

  公开（公告）日：2012-06-06

  The invention provides amino-substituted aminothiazole compounds of Formula I (Formula I) in which A is a group of the formula: and the variables R and R1 to R7 are described herein. These compounds are useful as inhibitors of viral replication. Compositions containing such compounds, and methods of treating viral infections with these compounds, as well as to processes and intermediates useful for preparing such compounds are also provided by the invention.

  本发明提供了式 I 的氨基取代氨基噻唑化合物（式 I），其中 A 是式中的一个基团： 变量 R 和 R1 至 R7 如本文所述。这些化合物可作为病毒复制的抑制剂。本发明还提供了含有这些化合物的组合物、用这些化合物治疗病毒感染的方法以及制备这些化合物的工艺和中间体。