5-Chloro-3-hydroxyquinazoline-2,4(1H,3H)-dione | 824983-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-Chloro-3-hydroxyquinazoline-2,4(1H,3H)-dione
• 英文别名: 5-chloro-3-hydroxy-1H-quinazoline-2,4-dione
• CAS: 824983-79-1
• 化学式: C₈H₅ClN₂O₃
• 分子量: 212.59
• InChiKey: WOBAHOOLQNKVID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] DIHYDROTHIENO[3,2-b]PYRIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE DIHYDROTHIÉNO [3,2-B] PYRIDINE
  申请人：IDEAYA BIOSCIENCES INC

  公开号：WO2019067442A1

  公开（公告）日：2019-04-04

  Compounds are provided having Formula (I): wherein R, R1, Cyc and A have the meanings provided herein. The compounds have utility in the treatment of diseases, either alone or in combination with other agents.

  提供具有公式(I)的化合物：其中R、R1、Cyc和A具有本文件中提供的含义。这些化合物可用于治疗疾病，可以单独使用，也可以与其他药剂联合使用。
• [EN] 3-HYDROXY-QUINAZOLINE-2,4-DIONE DERIVATIVES AND THEIR USE AS NUCLEASE MODULATORS<br/>[FR] DÉRIVÉS DE 3-HYDROXY-QUINAZOLINE-2,4-DIONE ET LEUR UTILISATION COMME MODULATEURS DE NUCLÉASE
  申请人：LUDWIG INST FOR CANCER RES LTD

  公开号：WO2017051251A1

  公开（公告）日：2017-03-30

  Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FENl), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXOl) and/or GEN1.

  描述的化合物如下所示：或其药用盐，并用于调节翻翼核酸酶1（FEN1）、色素沉着性皮肤干裂症补体G蛋白（XPG）、外切核酸酶1（EXO1）和/或GEN1的方法中。
• 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
  申请人：Ludwig Institute for Cancer Research Ltd

  公开号：US11253521B2

  公开（公告）日：2022-02-22

  Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FEN1), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXO1) and/or GEN1.

  除其他外，描述了根据式 (I) 的化合物：或其药学上可接受的盐，以及在调节瓣膜内切酶 1 (FEN1)、色素沉着病补体 G 组蛋白 (XPG)、外切酶 1 (EXO1) 和/或 GEN1 的方法中的用途。
• 3-HYDROXY-7-(SULFONYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND 3-HYDROXY-PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES AND RELATED COMPOUNDS AS FLAP-ENDONUCLEASE 1 (FEN-1) INHIBITORS FOR USE IN CANCER THERAPY
  申请人：Ludwig Institute for Cancer Research Ltd

  公开号：EP3353154B1

  公开（公告）日：2020-08-19
• 3-HYDROXY-QUINAZOLINE-2,4-DIONE DERIVATIVES AND THEIR USE AS NUCLEASE MODULATORS
  申请人：Ludwig Institute for Cancer Research Ltd

  公开号：US20200237763A1

  公开（公告）日：2020-07-30

  Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FEN1), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXO1) and/or GEN1.