(RS)-4-(3-methoxy-quinoxalin-5-yl)-2,2-dimethyl-1,3-dioxa-8-aza-spiro[4,5]decane-8-carboxylic acid tert-butyl ester | 1163128-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: (RS)-4-(3-methoxy-quinoxalin-5-yl)-2,2-dimethyl-1,3-dioxa-8-aza-spiro[4,5]decane-8-carboxylic acid tert-butyl ester
• 英文别名: Tert-butyl 4-(3-methoxyquinoxalin-5-yl)-2,2-dimethyl-1,3-dioxa-8-azaspiro[4.5]decane-8-carboxylate
• CAS: 1163128-00-4
• 化学式: C₂₃H₃₁N₃O₅
• 分子量: 429.516
• InChiKey: YOSHSFMYTZAILM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  83
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES<br/>[FR] DÉRIVÉS 5-AMINOCYCLYLMÉTHYLOXAZOLIDIN-2-ONE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009077989A1

  公开（公告）日：2009-06-25

  The invention relates to antibacterial compounds of formula (I) wherein one or two of U, V, W, and X represent N, the rest represent CH or, in the case of X, may also represent CRa wherein Ra is fluorine; R1 represents alkoxy, halogen or cyano; R2 represents H, CH2OH, CH2N3, CH2NH2, alkylcarbonylaminomethyl or triazol- 1-ylmethyl; R3 represents H, or, when n is 1, R3 may also represent OH, NH2, NHCOR6 or triazol-1-yl; A represents CR4; K represents O, NH, OCH2, NHCO, NHCH2, CH2NH, CH2CH2, CH=CH, CHOHCHOH or CHR5; R4 represents H or together with R5 forms a bond, or also R4 can represent OH when K is not O, NH, OCH2 or NHCO; R5 represents OH or together with R4 forms a bond; R6 represents alkyl; m is O or 1 and n is O or 1; and G is as defined in the description; and to salts of such compounds.

  该发明涉及式(I)的抗菌化合物，其中U、V、W和X中的一个或两个代表N，其余代表CH或者在X的情况下，也可以代表CRa，其中Ra为氟；R1代表烷氧基、卤素或氰基；R2代表H、CH2OH、CH2N3、CH2NH2、烷基羰基氨甲基或三唑-1-基甲基；R3代表H，或者当n为1时，R3也可以代表OH、NH2、NHCOR6或三唑-1-基；A代表CR4；K代表O、NH、OCH2、NHCO、NHCH2、CH2NH、CH2CH2、CH=CH、CHOHCHOH或CHR5；R4代表H，或者与R5一起形成键，或者当K不是O、NH、OCH2或NHCO时，R4也可以代表OH；R5代表OH，或者与R4一起形成键；R6代表烷基；m为O或1，n为O或1；G如描述中所定义；以及这些化合物的盐。
• 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES
  申请人：Hubschwerlen Christian

  公开号：US20110003789A1

  公开（公告）日：2011-01-06

  The invention relates to antibacterial compounds of formula I wherein one or two of U, V, W, and X represent N, the rest represent CH or, in the case of X, may also represent CR a wherein R a is fluorine; R 1 represents alkoxy, halogen or cyano; R 2 represents H, CH 2 OH, CH 2 N 3 , CH 2 NH 2 , alkylcarbonylaminomethyl or triazol-1-ylmethyl; R 3 represents H, or, when n is 1, R 3 may also represent OH, NH 2 , NHCOR 6 or triazol-1-yl; A represents CR 4 ; K represents O, NH, OCH 2 , NHCO, NHCH 2 , CH 2 NH, CH 2 CH 2 , CH═CH, CHOHCHOH or CHR 5 ; R 4 represents H or together with R 5 forms a bond, or also R 4 can represent OH when K is not O, NH, OCH 2 or NHCO; R 5 represents OH or together with R 4 forms a bond; R 6 represents alkyl; m is 0 or 1 and n is 0 or 1; and G is as defined in the description; and to salts of such compounds.

  本发明涉及式I的抗菌化合物，其中U、V、W和X中的一个或两个代表N，其余代表CH，或在X的情况下，也可以代表CRa，其中Ra是氟；R1代表烷氧基、卤素或氰基；R2代表H、CH2OH、CH2N3、CH2NH2、烷基羰基氨甲基或三唑-1-基甲基；R3代表H，或当n为1时，R3也可以代表OH、NH2、NHCOR6或三唑-1-基；A代表CR4；K代表O、NH、OCH2、NHCO、NHCH2、CH2NH、CH2CH2、CH═CH、CHOHCHOH或CHR5；R4代表H或与R5形成键，或当K不是O、NH、OCH2或NHCO时，R4也可以代表OH；R5代表OH或与R4形成键；R6代表烷基；m为0或1，n为0或1；G如描述中所定义；以及这些化合物的盐。
• US9505750B2
  申请人：——

  公开号：US9505750B2

  公开（公告）日：2016-11-29