N-(2-Hydroxyethyl)pentacosa-10,12-diynamide | 137870-33-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-Hydroxyethyl)pentacosa-10,12-diynamide
• CAS: 137870-33-8
• 化学式: C₂₇H₄₇NO₂
• 分子量: 417.7
• InChiKey: KMKKLXMLBOQSCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  30
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Arrays using polymerized monomolecular films and methods for using and manufacturing the same
  申请人：——

  公开号：US20030104451A1

  公开（公告）日：2003-06-05

  Devices and methods of use and manufacture for the identification and characterization of analytes, e.g. proteins, are provided. The subject devices are characterized by having a substrate with a polymerized monomolecular film over at least a portion of the substrate, the monomolecular film having at least one ligand or specific binding pair member associated therewith. Preferably the monomolecular film is stable to the laser intensities employed in MALDI-MS. In certain embodiments, the ligands are biotin, integrin antagonists, antibodies and antigens. In using the subject devices, a subject device is contacted with a sample. If present in the sample, a member of the binding pair of interest binds to its complementary ligand and, once bound, can be analyze by mass spectroscopy techniques. Also provided are kits, which include the subject devices.

  本发明提供了用于鉴定和表征蛋白质等分析物的装置和使用及制造方法。这些装置的特点是：有一个基底，基底的至少一部分上有一层聚合的单分子膜，单分子膜上有至少一个配体或特异性结合对成员。单分子膜最好对 MALDI-MS 中使用的激光强度稳定。在某些实施方案中，配体是生物素、整合素拮抗剂、抗体和抗原。在使用主体设备时，主体设备与样品接触。如果样品中存在感兴趣的结合配对，其成员就会与其互补配体结合，一旦结合，就可以通过质谱技术进行分析。此外，还提供了包括主题装置在内的试剂盒。
• Method for evaluating drug candidates
  申请人：ANALYTICAL BIOLOGICAL SERVICES, INC.

  公开号：US20040023303A1

  公开（公告）日：2004-02-05

  Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or transcellular permeability of a compound by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the compound and comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.

  二维和/或三维聚合物或扩展固体阵列（如聚二乙烯骨架阵列）可用于评估化合物的有机/水分配系数和/或口服吸收率和/或跨细胞渗透性，方法是监测暴露于化合物时阵列荧光或磷光的变化，并分别与已知的荧光或磷光变化进行比较。该方法还可用于评估化合物与蛋白质结合的能力。
• EP1546715A4
  申请人：——

  公开号：EP1546715A4

  公开（公告）日：2007-01-10
• METHOD FOR EVALUATING DRUG CANDIDATES
  申请人：Analytical Biological Services, Inc.

  公开号：EP1546715A2

  公开（公告）日：2005-06-29
• EP1907563A4
  申请人：——

  公开号：EP1907563A4

  公开（公告）日：2009-04-22