N-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-formamide | 53567-09-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-formamide
• 英文别名: N-(5-phenyl-1,3,4-thiadiazol-2-yl)formamide
• CAS: 53567-09-2
• 化学式: C₉H₇N₃OS
• 分子量: 205.24
• InChiKey: JEYGRXYLXFQJHI-UHFFFAOYSA-N

物化性质

• 熔点：
  201-203 °C
• 沸点：
  374.3±25.0 °C(Predicted)
• 密度：
  1.392±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲酸 、 2-氨基-5-苯基-1,3,4-噻二唑 在 polyethylene glycol-400 作用下， 反应 2.0h， 以94%的产率得到N-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-formamide
  参考文献：
  名称：

  Synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with potential bioactivity in PEG-400

  摘要：

  An environmental benign procedure for synthesis of 2-(N-formyl)-5-aryl/aryloxymethyl-1,3,4-thiadiazoles has been developed by reaction of 2-amino-5-aryl/aryloxymethyl-1,3,4-thiadiazoles with formic acid in PEG-400. The key advantages of this protocol are the shorter reaction time, higher yields, lower cost, simple workup, and environment-friendly compared to conventional organic solvent reaction. The present method does not involve any hazardous organic solvent or catalyst. (C) 2009 Xi Cun Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2009.11.045

文献信息

• Antitumor activity of 5-substituted 2-acylamino-1,3,4-thiadiazoles against transplantable rodent tumors.
  作者：KENICHI MIYAMOTO、RYOZO KOSHIURA、MASAO MORI、HIDEHARU YOKOI、CHIKA MORI、TAKAAKI HASEGAWA、KICHITARO TAKATORI

  DOI：10.1248/cpb.33.5126

  日期：——

  The antitumor activities of twelve 2-N-and/or 5-substituted 2-amino-1, 3, 4-thiadiazole analogs were tested on Lewis lung carcinoma in mice by intraperitoneal administration. 2-Amino-1, 3, 4-thiadiazole (ATDA), 2-formamido-1, 3, 4-thiadiazole and 2-trifluoroacetamido-1, 3, 4-thiadiazole significantly prolonged the life span of tumor bearing mice. 5-Substituted analogs and 2-urethane and 2-carbamate type compounds were inactive. 2-Formamido-1, 3, 4-thiadiazole showed more potent activity than the parent compound ATDA against P388, L1210 leukemia, B16 melanoma and Lewis lung carcinoma. The differences in the antitumor activity among ATDA analogs are discussed.

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• NPY Y5 antagonist
  申请人：Kawanishi Yasuyuki

  公开号：US20070015762A1

  公开（公告）日：2007-01-18

  The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R 1 is lower alkyl, cycloalkyl or the like, R 2 is hydrogen, lower alkyl or the like, n is 1 or 2, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, Y is CONR 7 , CSNR 7 , NR 7 CO, NR 7 CS or the like, Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like and R 7 is hydrogen or lower alkyl, prodrug, pharmaceutically acceptable salt or solvate thereof

  本发明提供了一种用作NPY Y5受体拮抗剂的药物组合物，包括公式（I）中的化合物： 其中R1是较低的烷基、环烷基或类似物，R2是氢、较低的烷基或类似物，n为1或2，X为较低的烷基、较低的烯基、芳基、环烷基或类似物，Y为CONR7、CSNR7、NR7CO、NR7CS或类似物，Z为较低的烷基、可选择的取代的碳环烷基、可选择的取代的杂环烷基或类似物，R7为氢或较低的烷基，前药、药学上可接受的盐或溶剂。
• US7781461B2
  申请人：——

  公开号：US7781461B2

  公开（公告）日：2010-08-24