2-amino-1-(1-benzyl-1H-indazol-3-yl)ethanol | 1186509-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 2-amino-1-(1-benzyl-1H-indazol-3-yl)ethanol
• 英文别名: 2-Amino-1-(1-benzylindazol-3-yl)ethanol
• CAS: 1186509-36-3
• 化学式: C₁₆H₁₇N₃O
• 分子量: 267.33
• InChiKey: QSVUXVXHSSAGNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  64.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(1-benzylindazol-3-yl)-2-nitroethanol 在 镍 氢气 作用下， 反应 3.0h， 生成 2-amino-1-(1-benzyl-1H-indazol-3-yl)ethanol
  参考文献：
  名称：

  [EN] 1-BENZYL-3-HYDR0XYMETHYLINDAZ0LE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, AND CX3CR1
  [FR] NOUVEAUX DÉRIVÉS DE 1-BENZYL-3-HYDROXYMÉTHYLINDAZOLE ET LEUR UTILISATION DANS LE TRAITEMENT DES MALADIES BASÉES SUR L'EXPRESSION DE MCP-1 ET CX3CR1

  摘要：

  公开号：

  WO2009109654A8

文献信息

• 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CXCR1 AND P40
  申请人：Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.

  公开号：EP2262777B1

  公开（公告）日：2016-02-24
• 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CRI
  申请人：Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.

  公开号：EP2262777A2

  公开（公告）日：2010-12-22
• COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING OCULAR DISORDERS
  申请人：Translatum Medicus, Inc.

  公开号：EP3310353A1

  公开（公告）日：2018-04-25
• 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1 AND CX3CR1
  申请人：Guglielmotti Angelo

  公开号：US20100317618A1

  公开（公告）日：2010-12-16

  The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of novel 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1 and CX3CR1, and to their use in a method for treating or preventing diseases based on the expression of MCP-1 and CX3CR1.
• US8314099B2
  申请人：——

  公开号：US8314099B2

  公开（公告）日：2012-11-20