2-Phenyl-2-(piperazin-1-yl)ethan-1-ol | 1179067-18-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Phenyl-2-(piperazin-1-yl)ethan-1-ol
• 英文别名: 2-phenyl-2-piperazin-1-ylethanol
• CAS: 1179067-18-5
• 化学式: C₁₂H₁₈N₂O
• 分子量: 206.28
• InChiKey: CPPBQCJPEHLWEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel phenylpiperazine derivatives, process for preparing them and therapeutic compositions containing them
  申请人：JUSTE, S.A. QUIMICO-FARMACEUTICA

  公开号：EP0141884A1

  公开（公告）日：1985-05-22

  Novel phenylpiperazine derivatives of phenylpropionic acid, of general formula: wherein R1 is a hydrogen or chlorine atom or a trifluoromethyl group and pharmaceutically acceptable salts thereof, a process for their production, and pharmaceutical compositions containing the same are disclosed. The compounds have analgesic properties.

  本发明涉及苯基丙酸的新型苯基哌嗪衍生物，其通式为：其中R1为氢、氯或三氟甲基基团及其药学上可接受的盐，公开了其制备过程和含有该化合物的药物组合物。这些化合物具有镇痛作用。
• NOVEL PYRIMIDINE DERIVATIVES 698
  申请人：Ashton Susan Elizabeth

  公开号：US20080242663A1

  公开（公告）日：2008-10-02

  The invention concerns compounds of Formula I, or a pharmaceutically acceptable salt thereof, where R 1 , n, R 2 , R 3 , and R 4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.

  本发明涉及公式I的化合物或其药学上可接受的盐，其中R1、n、R2、R3和R4如描述中所定义。本发明还涉及制备这种化合物的方法、包含它们的药物组合物以及它们在制造用于作为抗增殖剂用于预防或治疗对EphB4激酶抑制敏感的肿瘤或其他增殖性疾病的药物的用途。
• US4096260A
  申请人：——

  公开号：US4096260A

  公开（公告）日：1978-06-20