N-[2-(2-dimethylamino-ethyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ'-benzo[d]isothiazol-6-yl]-2-[(pyridin-4-ylmethyl)-amino]-nicotinamide | 453564-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-[2-(2-dimethylamino-ethyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ'-benzo[d]isothiazol-6-yl]-2-[(pyridin-4-ylmethyl)-amino]-nicotinamide
• 英文别名: N-[2-[2-(dimethylamino)ethyl]-3,3-dimethyl-1,1-dioxo-1,2-benzothiazol-6-yl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
• CAS: 453564-39-1
• 化学式: C₂₅H₃₀N₆O₃S
• 分子量: 494.618
• InChiKey: BJOIGSBGGJUKKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Substituted alkylamine derivatives and methods of use
  申请人：Chen Guoqing

  公开号：US20060040956A1

  公开（公告）日：2006-02-23

  Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的杂环化合物可用于预防和治疗由血管生成介导的疾病等疾病。本发明涵盖了新型化合物，类似物，前药和其药学上可接受的衍生物，药物组合物和预防和治疗涉及癌症等疾病和其他疾病或疾病状况的方法。本发明还涉及制备这样的化合物的过程，以及在这样的过程中有用的中间体。