2-Hydroxy-naphthaldehyd-imin | 55135-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Hydroxy-naphthaldehyd-imin
• 英文别名: (2-hydroxy-1-naphthylmethylene) amine；2-Naphthalenol, 1-(iminomethyl)-；1-methanimidoylnaphthalen-2-ol
• CAS: 55135-69-8
• 化学式: C₁₁H₉NO
• 分子量: 171.199
• InChiKey: ZNULUGOEZRSLQL-UHFFFAOYSA-N

物化性质

• 沸点：
  328.3±44.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Hydroxy-naphthaldehyd-imin 以 乙醇 为溶剂， 生成 8,16-oxa-8H,16H-dinaphtho<2,1-b:2,1-f><1,5>dioxocin 、 8,16-imino-8H,16H-dinaphtho<2,1-b,f>-1,5-dioxocin
  参考文献：
  名称：

  Preparation of 8,16-Imino-8H,16H-dinaphtho[2,1-b:2,1-f][1,5]dioxocin

  摘要：

  DOI：

  10.3987/com-95-7382
• 作为产物：
  描述：

  2-羟基-1-萘甲醛 生成 2-Hydroxy-naphthaldehyd-imin
  参考文献：
  名称：

  Kazitsyna,L.A. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 286 - 294

  摘要：

  DOI：

文献信息

• Theramutein modulators
  申请人：Housey Gerad M.

  公开号：US20100016298A1

  公开（公告）日：2010-01-21

  This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

  这项发明涉及的是抑制或激活内源性蛋白变异形式的试剂以及识别这些变异的新方法。特别感兴趣的是那些由突变基因编码的内源性蛋白变异的抑制剂和激活剂，这些变异通常是在暴露于已知是相应未突变内源性蛋白的抑制剂或激活剂的化学试剂之后出现，或者至少是首次被识别为由此类化学试剂引起的。
• [EN] RUTHENIUM- OR OSMIUM-BASED COMPLEX CATALYSTS<br/>[FR] CATALYSEURS COMPLEXES À BASE DE RUTHÉNIUM OU D'OSMIUM
  申请人：LANXESS DEUTSCHLAND GMBH

  公开号：WO2014198658A1

  公开（公告）日：2014-12-18

  The present invention provides novel ruthenium or osmium based complex structures with a unique combination of ligands comprising a Schiff-base type ligand, a N-heterocyclic carbene ligand and a CO ligand which can be prepared according to two different routes involving easily accessible starting materials and which represent excellent catalysts for hydrogenating unsaturated compounds, oligomers and polymers, in particular at unforeseeably low temperatures.

  本发明提供了一种新颖的以钌或锇为基础的复合结构，具有独特的配体组合，包括席夫碱型配体、N-杂环卡宾配体和CO配体，可以根据两种不同的途径制备，涉及易获得的起始材料，并且代表了在意想不到的低温下对不饱和化合物、寡聚物和聚合物进行氢化的优秀催化剂。
• [EN] BLEACH CATALYSTS<br/>[FR] CATALYSEURS DE BLANCHIMENT
  申请人：BASF SE

  公开号：WO2012080088A1

  公开（公告）日：2012-06-21

  The present invention relates to specific acylhydrazone compounds, their use as oxidation catalysts and to a process for removing stains and soil on textiles and hard surfaces. The compounds are substituted with a specific cyclic ammonium group adjacent to the acyl group. Further aspects of the invention are compositions or formulations comprising such compounds.

  本发明涉及特定的酰基腙化合物，它们作为氧化催化剂的用途以及用于去除纺织品和硬表面上的污渍和污垢的过程。这些化合物在酰基旁边被特定的环氨基取代。发明的其他方面是包含这些化合物的组合物或配方。
• IDO Inhibitors
  申请人：Mautino Mario

  公开号：US20110053941A1

  公开（公告）日：2011-03-03

  Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

  目前提供以下方法：(a) 通过接触本文中描述的化合物的调节有效量与吲哚胺2,3-二氧化酶相互作用，从而调节吲哚胺2,3-二氧化酶的活性；(b) 治疗需要吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制的患者，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(c) 治疗需要抑制吲哚胺-2,3-二氧化酶酶活性的医疗状况，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(d) 增强抗癌治疗的有效性，包括给予抗癌剂和本文中描述的化合物；(e) 治疗与癌症相关的肿瘤特异性免疫抑制，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(f) 治疗与传染病相关的免疫抑制，例如HIV-1感染，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量。
• Bleach catalysts
  申请人：BASF SE

  公开号：EP2805942A1

  公开（公告）日：2014-11-26

  The present invention relates to specific acylhydrazone compounds, their use as oxidation catalysts and to a process for removing stains and soil on textiles and hard surfaces. The compounds are substituted with a specific cyclic ammonium group adjacent to the acyl group. Further aspects of the invention are compositions or formulations comprising such compounds.

  本发明涉及特定的酰基腙化合物、其作为氧化催化剂的用途以及去除纺织品和硬表面污渍和污垢的工艺。这些化合物在酰基附近被特定的环状铵基取代。本发明的其他方面是包含此类化合物的组合物或制剂。